{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:19:01Z","timestamp":1783696741500,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Pharma AG, Switzerland"},{"name":"Movember Global Action Plan (GAP1)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is an urgent need for preclinical models of prostate cancer; however, clinically relevant patient\u2010derived prostate cancer xenografts (PDXs) are demanding to establish.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven patients who were undergoing palliative transurethral surgery or radical prostatectomy for histologically confirmed, clinically relevant prostate cancer were included in the study. Fresh prostate cancer tissue was identified by frozen analysis in 48 patients. The cancer tissue was transplanted subcutaneously and under the renal capsule of NSG and NOG mice supplemented with human testosterone. All growing PDXs were evaluated by histology and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early assessment of the animals at least three months after transplantation included 27\/48 (56.3%) eligible PDX cohorts. PDX growth was detected in 10\/27 (37%) mouse cohorts. Eight of the ten PDXs were identified as human donor derived lymphomas, including seven Epstein Barr virus (EBV)\u2010positive diffuse large B\u2010cell lymphomas and one EBV\u2010negative peripheral T\u2010cell lymphoma. One sample consisted of benign prostatic tissue, and one sample comprised a benign epithelial cyst. Prostate cancer was not detected in any of the samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tumors that arise within the first three months after prostate cancer xenografting may represent patient\u2010derived EBV\u2010positive lymphomas in up to 80% of the early growing PDXs when using triple knockout NSG immunocompromised mice. Therefore, lymphoma should be excluded in prostate cancer xenografts that do not resemble typical prostatic adenocarcinoma. <jats:italic>Prostate 75: 585\u2013592, 2015<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.22939","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T03:13:55Z","timestamp":1421205235000},"page":"585-592","source":"Crossref","is-referenced-by-count":59,"title":["Early development of human lymphomas in a prostate cancer xenograft program using triple knock\u2010out Immunocompromised mice"],"prefix":"10.1002","volume":"75","author":[{"given":"Christian","family":"Wetterauer","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Vlajnic","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Basel Basel 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