{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:46:26Z","timestamp":1775706386420,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570682"],"award-info":[{"award-number":["81570682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300625"],"award-info":[{"award-number":["81300625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400755"],"award-info":[{"award-number":["81400755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Complications after a thulium laser resection of the prostate (TmLRP) are related to re\u2010epithelialization of the prostatic urethra. Since prostate growth and development are induced by androgen, the aim of this study was to determine the role and explore the mechanism of androgen in wound healing of the prostatic urethra.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Beagles that received TmLRPs were randomly distributed into a castration group, a testosterone undecanoate (TU) group, and a control group. The prostate wound was assessed once a week using a cystoscope. Histological analysis was then carried out to study the re\u2010epithelialization of the prostatic urethra in each group. The inflammatory response in the wound tissue and urine was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The healing of the prostatic urethra after a TmLRP was more rapid in the castration group and slower in the TU group than that in the control group. Castration accelerated re\u2010epithelialization by promoting basal cell proliferation in the wound surface and beneath the wound and by accelerating the differentiation of basal cells into urothelial cells. Castration reduced the duration of the inflammatory phase and induced the conversion of M1 macrophages to M2 macrophages, thus accelerating the maturation of the wound. By contrast, androgen supplementation enhanced the inflammatory response and prolonged the inflammatory phase. Moreover, the anti\u2010inflammatory phase was delayed and weakened.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Androgen deprivation promotes re\u2010epithelialization of the wound, regulates the inflammatory response, and accelerates wound healing of the prostatic urethra after a TmLRP. <jats:italic>Prostate 77:708\u2013717, 2017<\/jats:italic>. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23301","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T09:16:44Z","timestamp":1486459004000},"page":"708-717","source":"Crossref","is-referenced-by-count":21,"title":["Androgen Deprivation Accelerates the Prostatic Urethra Wound Healing After Thulium Laser Resection of the Prostate by Promoting Re\u2010Epithelialization and Regulating the Macrophage Polarization"],"prefix":"10.1002","volume":"77","author":[{"given":"Xing\u2010Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Department of Urology Shanghai General Hospital of Nanjing Medical University Shanghai China"},{"name":"Institute of Urology Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Heng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Guizhou Provincial People's Hospital Guiyang 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Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital of Nanjing Medical University Shanghai China"},{"name":"Department of Urology Wujin Hospital Affiliated Jiang Su University Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital of Nanjing Medical University Shanghai China"},{"name":"Department of Urology General Hospital of Xuzhou Mining Group Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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