{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:48:17Z","timestamp":1762004897512,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Ellrodt-Schweighauser Family Chair of Cancer Genomic Research of NorthShore University Health System"},{"name":"National Key Basic Research Program Grant 973 of China","award":["2012CB518301"],"award-info":[{"award-number":["2012CB518301"]}]},{"name":"Shanghai Outstanding Reward for Youth Doctor"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA148463"],"award-info":[{"award-number":["CA148463"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130047","81402339"],"award-info":[{"award-number":["81130047","81402339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prostate"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1002\/pros.23369","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T04:22:37Z","timestamp":1499055757000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":8,"title":["Reclassification of prostate cancer risk using sequentially identified SNPs: Results from the REDUCE trial"],"prefix":"10.1002","volume":"77","author":[{"given":"Haitao","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Genomic Translational Medicine and Prevention, School of Public Health; Fudan University; Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Fudan Institute of Urology, Huashan Hospital; Fudan University; Shanghai P. R. China"},{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh T.","family":"Packiam","sequence":"additional","affiliation":[{"name":"Section of Urology; University of Chicago Medical Center; Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly A.","family":"Conran","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deke","family":"Jiang","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Tao","sequence":"additional","affiliation":[{"name":"Center for Genomic Translational Medicine and Prevention, School of Public Health; Fudan University; Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Yu","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Lin","sequence":"additional","affiliation":[{"name":"Fudan Institute of Urology, Huashan Hospital; Fudan University; Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health; Fudan University; Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Lilly","family":"Zheng","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Brendler","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Helfand","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-6627","authenticated-orcid":false,"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Genomic Translational Medicine and Prevention, School of Public Health; Fudan University; Shanghai P. R. China"},{"name":"Fudan Institute of Urology, Huashan Hospital; Fudan University; Shanghai P. R. China"},{"name":"NorthShore University HealthSystem; Program for Personalized Cancer Care; Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,2]]},"reference":[{"key":"10.1002\/pros.23369-BIB0001|pros23369-cit-0001","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ng2022","article-title":"Genome-wide association study of prostate cancer identifies a second risk locus at 8q24","volume":"39","author":"Yeager","year":"2007","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0002|pros23369-cit-0002","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng2062","article-title":"Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes","volume":"39","author":"Gudmundsson","year":"2007","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0003|pros23369-cit-0003","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ng.89","article-title":"Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer","volume":"40","author":"Gudmundsson","year":"2008","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0004|pros23369-cit-0004","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.91","article-title":"Multiple loci identified in a genome-wide association study of prostate cancer","volume":"40","author":"Thomas","year":"2008","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0005|pros23369-cit-0005","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.90","article-title":"Multiple newly identified loci associated with prostate cancer susceptibility","volume":"40","author":"Eeles","year":"2008","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0006|pros23369-cit-0006","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.444","article-title":"Identification of a new prostate cancer susceptibility locus on chromosome 8q24","volume":"41","author":"Yeager","year":"2009","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0007|pros23369-cit-0007","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ng.450","article-title":"Identification of seven new prostate cancer susceptibility loci through a genome-wide association study","volume":"41","author":"Eeles","year":"2009","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0008|pros23369-cit-0008","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ng.448","article-title":"Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility","volume":"41","author":"Gudmundsson","year":"2009","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0009|pros23369-cit-0009","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.635","article-title":"Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population","volume":"42","author":"Takata","year":"2010","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0010|pros23369-cit-0010","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/ng.839","article-title":"Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21","volume":"43","author":"Haiman","year":"2011","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0011|pros23369-cit-0011","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ng.882","article-title":"Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study","volume":"43","author":"Kote-Jarai","year":"2011","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0012|pros23369-cit-0012","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ng.1104","article-title":"Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese","volume":"44","author":"Akamatsu","year":"2012","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0013|pros23369-cit-0013","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/ng.2424","article-title":"Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4","volume":"44","author":"Xu","year":"2012","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0014|pros23369-cit-0014","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ng.2560","article-title":"Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array","volume":"45","author":"Eeles","year":"2013","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0015|pros23369-cit-0015","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/ng.3094","article-title":"A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer","volume":"46","author":"Al Olama","year":"2014","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0016|pros23369-cit-0016","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1158\/2159-8290.CD-15-0315","article-title":"A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences","volume":"5","author":"Hoffmann","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1002\/pros.23369-BIB0017|pros23369-cit-0017","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1056\/NEJMoa075819","article-title":"Cumulative association of five genetic variants with prostate cancer","volume":"358","author":"Zheng","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1002\/pros.23369-BIB0018|pros23369-cit-0018","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.eururo.2012.05.006","article-title":"Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial","volume":"62","author":"Kader","year":"2012","journal-title":"Eur Urol"},{"key":"10.1002\/pros.23369-BIB0019|pros23369-cit-0019","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/1008-682X.179529","article-title":"Personalized prostate cancer care: from screening to treatment","volume":"18","author":"Conran","year":"2016","journal-title":"Asian J Androl"},{"key":"10.1002\/pros.23369-BIB0020|pros23369-cit-0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13073-016-0272-5","article-title":"Reclassification of genetic-based risk predictions as GWAS data accumulate","volume":"8","author":"Krier","year":"2016","journal-title":"Genome Med"},{"key":"10.1002\/pros.23369-BIB0021|pros23369-cit-0021","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1056\/NEJMoa0908127","article-title":"Effect of dutasteride on the risk of prostate cancer","volume":"362","author":"Andriole","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1002\/pros.23369-BIB0022|pros23369-cit-0022","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"Marchini","year":"2007","journal-title":"Nat Genet"},{"key":"10.1002\/pros.23369-BIB0023|pros23369-cit-0023","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1002\/pros.23369-BIB0024|pros23369-cit-0024","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/pros.23037","article-title":"Prediction of individual genetic risk to prostate cancer using a polygenic score","volume":"75","author":"Szulkin","year":"2015","journal-title":"Prostate"},{"key":"10.1002\/pros.23369-BIB0025|pros23369-cit-0025","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1158\/1055-9965.EPI-14-0317","article-title":"Risk analysis of prostate cancer in PRACTICAL, a multinational consortium, using 25 known prostate cancer susceptibility loci","volume":"24","author":"Amin Al Olama","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1002\/pros.23369-BIB0026|pros23369-cit-0026","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/gim.2014.192","article-title":"Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis","volume":"17","author":"Pashayan","year":"2015","journal-title":"Genet Med"},{"key":"10.1002\/pros.23369-BIB0027|pros23369-cit-0027","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/1008-682X.179527","article-title":"Population-standardized genetic risk score: the SNP-based method of choice for inherited risk assessment of prostate cancer","volume":"18","author":"Conran","year":"2016","journal-title":"Asian J Androl"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.23369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pros.23369\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T04:42:04Z","timestamp":1625460124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.23369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,2]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1002\/pros.23369","archive":["Portico"],"relation":{},"ISSN":["0270-4137"],"issn-type":[{"type":"print","value":"0270-4137"}],"subject":[],"published":{"date-parts":[[2017,7,2]]}}}