{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:02:23Z","timestamp":1776481343243,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572536 81672850"],"award-info":[{"award-number":["81572536 81672850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14140901700"],"award-info":[{"award-number":["14140901700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411969800"],"award-info":[{"award-number":["16411969800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy\u2010naive metastatic castration\u2010resistant prostate cancer (mCRPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an analysis in 115 chemotherapy\u2010na\u00efve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone\u2010specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment. Comparative <jats:italic>t<\/jats:italic>\u2010test was used to evaluate the serial changes of serum NED markers during AA treatment and univariate and multivariate analyses were performed to test the influence of AA treatment on NED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum CgA were NSE were evaluated to be above the upper limit of normal (ULN) in 56 (48.7%) and 29 (25.2%) patients before chemotherapy. In 34 patients with serial evaluation, serum CgA level of 14 patients and NSE of 14 patients increased after the failure of AA treatment. There was no significant difference of NED markers (CgA or NSE variation (<jats:italic>P<\/jats:italic>\u2009=\u20090.243) between at baseline and after the failure of AA treatment. Compared with the CgA elevation group in the first 6 months of AA treatment and baseline supranormal CgA group, the CgA decline group, and baseline normal CgA group has a much longer median PSA PFS (14.34 vs 10.00 months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, and 14.23 vs 10.30 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and rPFS, respectively (18.33 vs 11.37 months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, and 17.10 vs 12.07 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). In logistic univariate analysis, AA treatment and its duration were not independent factors influencing NED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We hypothesized that AA might not significantly lead to progression of NED of mCRPC in general. Furthermore, we found there was heterogeneity in changes of NED markers in different mCRPC patients during AA treatment. Serial CgA and NSE evaluation might help clinicians guide clinical treatment of mCRPC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23397","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T05:39:07Z","timestamp":1502689147000},"page":"1373-1380","source":"Crossref","is-referenced-by-count":18,"title":["Influence of abiraterone acetate on neuroendocrine differentiation in chemotherapy\u2010naive metastatic castration\u2010resistant prostate cancer"],"prefix":"10.1002","volume":"77","author":[{"given":"Baijun","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Urology Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liancheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Urology Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai 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