{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:46:32Z","timestamp":1780609592971,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ultrasense MR","award":["EFRO: 2010-013177"],"award-info":[{"award-number":["EFRO: 2010-013177"]}]},{"name":"PCMM","award":["03-O-203"],"award-info":[{"award-number":["03-O-203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non\u2010invasive techniques for the detection of clinically significant disease, leading to a reduction of over\u2010diagnosis and over\u2010treatment. The aim of this study was to determine the association between a novel urinary biomarker\u2010based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies. A subset of these patients also underwent a mpMRI scan of the prostate. The indications for performing mpMRI were based on persistent clinical suspicion of PCa or local staging after PCa was found upon biopsy. All mpMRI images were centrally reviewed in 2016 by an experienced radiologist blinded for the urine test results and biopsy outcome. The PI\u2010RADS version 2 was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 172 patients were included for analysis. Hundred (58%) patients had PCa detected upon prostate biopsy, of which 52 (52%) had high\u2010grade disease correlated with a significantly higher SelectMDx score (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The median SelectMDx score was significantly higher in patients with a suspicious significant lesion on mpMRI compared to no suspicion of significant PCa (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01). For the prediction of mpMRI outcome, the area\u2010under\u2010the\u2010curve of SelectMDx was 0.83 compared to 0.66 for PSA and 0.65 for PCA3. There was a positive association between SelectMDx score and the final PI\u2010RADS grade. There was a statistically significant difference in SelectMDx score between PI\u2010RADS 3 and 4 (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01) and between PI\u2010RADS 4 and 5 (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel urinary biomarker\u2010based SelectMDx score is a promising tool in PCa detection. This study showed promising results regarding the correlation between the SelectMDx score and mpMRI outcomes, outperforming PCA3. Our results suggest that this risk score could guide clinicians in identifying patients at risk for significant PCa and selecting patients for further radiological diagnostics to reduce unnecessary procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23401","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T04:20:55Z","timestamp":1504066855000},"page":"1401-1407","source":"Crossref","is-referenced-by-count":69,"title":["A urinary biomarker\u2010based risk score correlates with multiparametric MRI for prostate cancer detection"],"prefix":"10.1002","volume":"77","author":[{"given":"Rianne J.","family":"Hendriks","sequence":"first","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes M. G.","family":"van der Leest","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siebren","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle O.","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Criekinge","sequence":"additional","affiliation":[{"name":"Department of Mathematical Modeling Statistics and Bio\u2010Informatics Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Hulsbergen\u2010van de Kaa","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Schalken","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F. A.","family":"Mulders","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-1869","authenticated-orcid":false,"given":"Inge M.","family":"van Oort","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.046"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.12.062"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.01.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0178"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29874"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13427"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13318"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1655-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140611347"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13504"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09286.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00759-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3334"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.04.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2377-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173646.99337.b1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11611.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1192"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.23401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.23401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:07:29Z","timestamp":1696475249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.23401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":21,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/pros.23401"],"URL":"https:\/\/doi.org\/10.1002\/pros.23401","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}