{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:09:25Z","timestamp":1777604965724,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HealthTronics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the ability of salvage cryoablation of the prostate (SCAP) to delay the need for androgen deprivation therapy (ADT) in local recurrence after radiation therapy to the prostate using the Cryo\u2010On\u2010Line Database (COLD) registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The COLD registry is comprised of a combination of retrospectively and prospectively collected data on patients undergoing primary and SCAP. Patients with local recurrence after radiation therapy were identified. Kaplan\u2010Meier analysis was used to calculate ADT\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 898 patients that have undergone SCAP in the COLD registry. Overall, the calculated 5\u2010year ADT\u2010free survival probability was 0.713. When stratified by D'Amico risk group, 264 high\u2010risk patients (71.9%), 234 intermediate\u2010risk (86.7%),and 228 low\u2010risk (87.7%) were free of ADT post\u2010SCAP. This correlates with a 5\u2010year ADT\u2010free survival of 60.7, 73.9, and 82.4%, respectively. Patients with post\u2010SCAP PSA nadir of &lt;0.2\u2009ng\/mL had a 5 year ADT\u2010free survival of 87.1% compared to 48.7% with a PSA nadir \u22650.2\u2009ng\/mL. Pre\u2010operative ADT use or full versus partial gland SCAP did not have an effect on ADT use post\u2010operatively. In 118 (55.4%) of patients with post\u2010operative biochemical recurrence, ADT was not used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with local recurrence after radiation, SCAP is an option that provides a high chance of avoiding or delaying ADT. The potential to delay ADT and its associated side effects should be a part of counseling sessions with the patient when discussing treatment options for locally recurrent prostate cancer after radiation. Avoidance of ADT is more clinically relevant than PSA elevation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23406","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:06:50Z","timestamp":1504166810000},"page":"1446-1450","source":"Crossref","is-referenced-by-count":17,"title":["Avoidance of androgen deprivation therapy in radiorecurrent prostate cancer as a clinically meaningful endpoint for salvage cryoablation"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-9793","authenticated-orcid":false,"given":"Kevin B.","family":"Ginsburg","sequence":"first","affiliation":[{"name":"Department of Urology Wayne State University School of Medicine Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Elshafei","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland Ohio"},{"name":"Department of Urology Medical School Cairo University Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Stephen","family":"Jones","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Cher","sequence":"additional","affiliation":[{"name":"Department of Urology Wayne State University School of Medicine Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.051"},{"key":"e_1_2_8_3_1","first-page":"55","article-title":"ADT risks and side effects in advanced prostate cancer: cardiovascular and acute renal injury","volume":"29","author":"Crawford ED","year":"2015","journal-title":"Oncology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.02.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.12.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24283"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2497"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67533-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10238.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.04.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.04.027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.137"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-007925"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.23406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.23406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:07:36Z","timestamp":1696475256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.23406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":14,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/pros.23406"],"URL":"https:\/\/doi.org\/10.1002\/pros.23406","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}