{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:09:32Z","timestamp":1789546172987,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:sup>99m<\/jats:sup>Tc\u2010MIP\u20101404 (Progenics Pharmaceuticals, Inc., New York, NY) is a novel, SPECT\u2010compatible <jats:sup>99m<\/jats:sup>Tc\u2010labeled PSMA inhibitor for the detection of prostate cancer. We present results of its clinical use in a cohort of 225 men with histologically confirmed prostate cancer referred for workup of biochemical relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2013 to April 2017, <jats:sup>99m<\/jats:sup>Tc\u2010MIP1404\u2010scintigraphy was performed in 225 patients for workup of PSA biochemical relapse of prostate cancer. Whole\u2010body planar and SPECT\/CT images of the lower abdomen and thorax were obtained 3\u20104\u2009h p.i. of 710\u2009\u00b1\u200964 MBq <jats:sup>99m<\/jats:sup>Tc\u2010MIP\u20101404. Images were visually analyzed for presence and location of abnormal uptake. In addition, quantitative analysis of the SPECT\/CT data was carried out on a subset of 125 patients. Follow\u2010up reports of subsequent therapeutic interventions were available for 59% (139) of all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tracer\u2010positive lesions were detected in 77% (174\/225) of all patients. Detections occurred at the area of local recurrence in the prostate in 25% of patients (or a total of 56), with metastases in lymph nodes in 47% (105), bone in 27% (60), lung in 5% (12), and other locations in 2% (4) of patients. Detection rates were 90% at PSA levels \u22652\u2009ng\/mL and 54% below that threshold. Lesional SUVmax values were, on average, 32.2\u2009\u00b1\u200929.6 (0.8\u2013142.2), and tumor\u2010to\u2010normal ratios 146.6\u2009\u00b1\u2009160.5 (1.9\u20131482.4). The PSA level correlated significantly with total uptake of MIP\u20101404 in tumors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, total tumor uptake was significantly higher in patients with Gleason scores \u22658 compared to those with Gleason scores \u22647 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In patients with androgen deprivation therapy, the detection rate was significantly higher compared to patients without androgen deprivation therapy (86% vs 71%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Based on <jats:sup>99m<\/jats:sup>Tc\u2010MIP\u20101404\u2010imaging and other information, an interdisciplinary tumor board review recommended changes to treatment plans in 74% (104\/139) of those patients for whom the necessary documentation was available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SPECT\/CT with <jats:sup>99m<\/jats:sup>Tc\u2010labeled MIP\u20101404 has a high probability in detecting PSMA\u2010positive lesions in patients with elevated PSA. Statistical analysis disclosed significant relationship between quantitative <jats:sup>99m<\/jats:sup>Tc\u2010MIP\u20101404 uptake, PSA level, and Gleason score.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23444","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T08:12:36Z","timestamp":1509955956000},"page":"54-63","source":"Crossref","is-referenced-by-count":89,"title":["<sup>99m<\/sup>Tc\u2010MIP\u20101404\u2010SPECT\/CT for the detection of PSMA\u2010positive lesions in 225 patients with biochemical recurrence of prostate cancer"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-0058","authenticated-orcid":false,"given":"Christian","family":"Schmidkonz","sequence":"first","affiliation":[{"name":"Clinic of Nuclear Medicine University Hospital Erlangen Erlangen 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