{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:47:24Z","timestamp":1784018844924,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fund for Research and Progress in Urology"},{"name":"Johns Hopkins University School of Medicine"},{"DOI":"10.13039\/100007338","name":"Barnes-Jewish Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007338","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014571","name":"Alvin J. Siteman Cancer Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014571","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["T32CA190194"],"award-info":[{"award-number":["T32CA190194"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["P30CA006973"],"award-info":[{"award-number":["P30CA006973"]}]},{"name":"Patrick C. Walsh Prostate Cancer Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To extend our previous observation of a short\u2010term rise in prostate\u2010specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer\u2010term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow\u2010up in young active duty U.S. servicemen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured PSA in serum specimens collected in 1995\u20107 (baseline) and 2004\u20106 (follow\u2010up) from 265 men diagnosed with chlamydia (CT), 72 with gonorrhea (GC), 37 with non\u2010chlamydial, non\u2010gonococcal urethritis (NCNGU), 58 with infectious mononucleosis (IM), 91 with other systemic or non\u2010genitourinary infections such as varicella; and 125\u2010258 men with no infectious disease diagnoses in their medical record during follow\u2010up (controls). We examined the influence of these infections on PSA change between baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of men with any increase in PSA (&gt;0\u2009ng\/mL) over the 10\u2010year average follow\u2010up was significantly higher in men with histories of sexually transmitted infections (CT, GC, and NCNGU; 67.7% vs 60.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.043), systemic infections (66.7% vs 54.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.047), or any infections (all cases combined; 68.5% vs 54.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) in their military medical record compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While PSA has been previously shown to rise during acute infection, these findings demonstrate that PSA remains elevated over a longer period. Additionally, the overall infection burden, rather than solely genitourinary\u2010specific infection burden, contributed to these long\u2010term changes, possibly implying a role for the cumulative burden of infections in prostate cancer risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23660","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T04:39:29Z","timestamp":1527741569000},"page":"1024-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sustained influence of infections on prostate\u2010specific antigen concentration: An analysis of changes over 10 years of follow\u2010up"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-2425","authenticated-orcid":false,"given":"Marvin E.","family":"Langston","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Pakpahan","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remington L.","family":"Nevin","sequence":"additional","affiliation":[{"name":"The Quinism Foundation White River Junction Vermont"},{"name":"The Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo M.","family":"De Marzo","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland"},{"name":"Department of Urology and the James Buchanan Brady Urological Institute Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Gaydos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6599-6775","authenticated-orcid":false,"given":"William B.","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland"},{"name":"Department of Urology and the James Buchanan Brady Urological Institute Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland"},{"name":"Department of Urology and the James Buchanan Brady Urological Institute Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Department of Pharmacology Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori J.","family":"Sokoll","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland"},{"name":"Department of Urology and the James Buchanan Brady Urological Institute Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Zenilman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Platz","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland"},{"name":"Department of Urology and the James Buchanan Brady Urological Institute Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-8107","authenticated-orcid":false,"given":"Siobhan","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis Missouri"},{"name":"Alvin J. Siteman Cancer Center Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.06.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00892-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.271"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500535"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-6-25"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0480-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00164.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00372-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23392"},{"key":"e_1_2_8_11_1","first-page":"120535","article-title":"Chikungunya virus infection and acute elevation of serum prostate\u2010specific antigen","volume":"2015","author":"Aiken WD","year":"2015","journal-title":"Case Rep Urol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29966"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3434"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1158\/1055-9965.373.13.3","article-title":"Elevated prostate\u2010specific antigen levels up to 25 years prior to death from prostate cancer","volume":"13","author":"Kuller LH","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25568"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000169262.18000.8a"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.7527"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.92.12.1900"},{"key":"e_1_2_8_19_1","first-page":"7","article-title":"Updates: routine screening for antibodies to human immunodeficiency virus, type 1 (HIV\u20101), civilian applicants for US military service and US Armed Forces, active and reserve components","volume":"19","year":"2012","journal-title":"MSMR"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00372-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00164.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-2-19"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-017-0919-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.11.1338"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21392"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01304-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2090"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.256"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.23660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.23660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:24:28Z","timestamp":1695025468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.23660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,30]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/pros.23660"],"URL":"https:\/\/doi.org\/10.1002\/pros.23660","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,30]]},"assertion":[{"value":"2018-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}