{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:11:58Z","timestamp":1770991918017,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA090381"],"award-info":[{"award-number":["P50 CA090381"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA136578"],"award-info":[{"award-number":["R01CA136578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA141298"],"award-info":[{"award-number":["R01CA141298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA167552"],"award-info":[{"award-number":["UM1 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA09001"],"award-info":[{"award-number":["T32 CA09001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Corpora amylacea are amyloid bodies commonly found adjacent to damaged prostate epithelium. Little is known about their formation or function. The current study sought to characterize corpora amylacea in prostate tissue and to describe their relationship with clinical, histological, molecular, and lifestyle factors, especially with chronic inflammation which is associated with aggressive disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a cohort of 355 men with prostate cancer and tissue specimens from the Health Professionals Follow\u2010Up Study. Pathologists examined H&amp;E slides and undertook a standardized review for histologic data and inflammation. Trained observers counted corpora amylacea within the benign and predominately tumor areas. Immunohistochemistry biomarkers were available from tissue microarrays. We used multivariable logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) to assess associations of chronic inflammation, clinical, histological, molecular, and lifestyle factors with the presence of corpora amylacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Corpora amylacea were present in benign tissue area for 298 men (84%). Specimens with moderate\u2010to\u2010severe chronic inflammation were more likely to have corpora amylacea in benign regions (OR\u2009=\u20095.4 95%CI 1.9, 15.6). Moreover, corpora amylacea were more common in men with higher body mass index (OR\u2009=\u20091.13 95%CI 1.01, 1.26). In contrast, Gleason grade (OR\u2009=\u20090.4 95%CI 0.2, 0.8), proliferation index (OR\u2009=\u20090.6 95%CI 0.3, 1.2) and the presence of the <jats:italic>TMPRSS2:ERG<\/jats:italic> fusion (OR\u2009=\u20090.4 95%CI 0.2, 0.8) were inversely associated with corpora amylacea presence. TURP specimens were less likely to have corpora amylacea than prostatectomy specimens (OR\u2009=\u20090.12 95%CI 0.03, 0.47). Age, PSA, stage, biomarkers of angiogenesis and PTEN, and vasectomy were not significantly associated with corpora amylacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Corpora amylacea were common among men with prostate cancer and were associated with pro\u2010inflammatory factors, some markers of less aggressive disease, and lack of the <jats:italic>TMPRSS2:ERG<\/jats:italic> fusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23692","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T04:22:02Z","timestamp":1531714922000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Corpora amylacea in prostatectomy tissue and associations with molecular, histological, and lifestyle factors"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-0467","authenticated-orcid":false,"given":"Natalie C.","family":"DuPre","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts"},{"name":"Channing Division of Network Medicine Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Flavin","sequence":"additional","affiliation":[{"name":"Department of Histopathology St. James's Hospital and Trinity College Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-3059","authenticated-orcid":false,"given":"Karen S.","family":"Sfanos","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Unger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"To","sequence":"additional","affiliation":[{"name":"Global Discovery Chemistry Novartis Institutes for BioMedical Research Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizaveta","family":"Gazeeva","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts"},{"name":"Pathology Unit Addarii Instituto, S. Orsola\u2010Malpighi Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo M.","family":"De Marzo","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Rider","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorelei A.","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Transdisciplinary Prostate Cancer Partnership(ToPCaP)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2017. 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