{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:22Z","timestamp":1786978342900,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013423","name":"OTTOGI Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013423","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The anti\u2010cancer activities of curcumin are well\u2010documented from preclinical studies using prostate cancer models. Our objective was to evaluate the anti\u2010cancer activity of oral curcumin in patients with prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, double\u2010blind, placebo\u2010controlled trial was performed on patients with prostate cancer who received intermittent androgen deprivation (IAD). Participants who finished the first on\u2010treatment period of IAD were randomized into a curcumin or placebo group. The patients took oral curcumin (1440\u2009mg\/day) or placebo for six months and were followed up until the beginning of the second on\u2010treatment. The primary end\u2010point was duration of the first off\u2010treatment. The secondary end\u2010points were change in PSA and testosterone levels during 6 months, PSA progression rate, and health\u2010related quality of life (HRQOL) scores at 6 months. Safety assessments included adverse event, adverse drug reaction, and serious adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 97 participants were randomized 1:1 to curcumin (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200949) and placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948) groups. Among them, 82 patients (84.5%) were evaluable for the analysis (39 and 43 patients in the curcumin and placebo groups, respectively). The median off\u2010treatment duration was 16.3 months (95% confidence interval [CI] 12.3\u201020.3 months) and 18.5 months (95% CI 12.5\u201023.0 months) in the curcumin and placebo groups, respectively. There was no significant difference in the curve of off\u2010treatment duration between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.4816). The proportion of patients with PSA progression during the active curcumin treatment period (6 months) was significantly lower in the curcumin group than the placebo group (10.3% vs 30.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0259). The change of PSA, testosterone levels during 6 months, and HRQOL scores at 6 months were not different between curcumin and placebo groups. Adverse events were higher in the placebo group (16 of 46 vs 7 of 45 patients,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0349). No significant differences in the adverse drug reaction were found between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Six months\u2019 intake of oral curcumin did not significantly affect the overall off\u2010treatment duration of IAD. However, PSA elevation was suppressed with curcumin intake during the curcumin administration period. Curcumin at this dose was well tolerated and safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.23766","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T03:43:00Z","timestamp":1548301380000},"page":"614-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["A randomized, double\u2010blind, placebo\u2010controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-9791","authenticated-orcid":false,"given":"Young Hyo","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok Hyun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon\u2010woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data center Samsung Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data center Samsung Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Hwan","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwang Gyun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong Chang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Il","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul 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