{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:33:13Z","timestamp":1776454393615,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Improved prostate cancer (PCa) survival by statin use has been reported among PCa patients managed with radiation or androgen deprivation therapy (ADT), while results are controversial for men managed surgically. We evaluate the association between cholesterol\u2010lowering medication with initiation of ADT and disease\u2010specific death among PCa cases who underwent radical prostatectomy in Finland between 1995 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort included 14\u2009424 men with PCa who underwent radical prostatectomy in Finland between 1995 and 2013. Cases were identified from national hospital discharge registry. Clinical data were amended from patient files of the treating hospitals. Information on co\u2010morbidities, additional radiation\u2010 or chemotherapy, and causes of deaths were collected from national registries. Personal\u2010level data on medication use during 1995\u20102014 were gathered from national prescription database. Registry linkages were carried out using personal identification number. Lipid\u2010lowering drugs were categorized into statins and non\u2010statin drugs. Risk of PCa death and initiation of ADT was analyzed using Cox\u2010regression model with adjustment for age, radiation therapy, chemotherapy, co\u2010morbidities and other drug use. Statin use was analyzed as time\u2010dependent variable. Delayed risk associations were evaluated in lag\u2010time analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to non\u2010users the risk of PCa death was significantly lower among statin users before PCa diagnosis (HR 0.70, 95%CIs 0.52\u20100.95). For statin use after PCa diagnosis the risk was lowered in age\u2010adjusted analysis (HR 0.76 95%CIs 0.62\u20100.93) but not after multivariable\u2010adjustment. Post\u2010diagnostic statin use was associated with improved PCa\u2010specific survival in 1, 3 and 5 years lag\u2010time analyses. The risk reduction was clearest for statin use initiated 5 years earlier (HR 0.71 95%CIs 0.55\u20100.92). Use of statins both before and after PCa diagnosis was associated with reduced risk of ADT use (HR 0.72 95%CIs 0.65\u20100.80 and HR 0.73, 95%CI 0.67\u20100.80, respectively). The risk of ADT decreased by increasing intensity of statin use before diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Statin use among surgically treated PCa patients has significant association with decreased risk of starting ADT and PCa death. The risk is lowered especially among men with statin use before PCa diagnosis and in men who used statins at high\u2010dose. Our results are hypothesis generating due to retrospective study design.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23768","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T04:35:19Z","timestamp":1547699719000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prostate cancer survival among statin users after prostatectomy in a Finnish nationwide cohort"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-7766","authenticated-orcid":false,"given":"Roni M.","family":"Joentausta","sequence":"first","affiliation":[{"name":"University of Tampere Faculty of Medicine and Health Technology Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Rannikko","sequence":"additional","affiliation":[{"name":"Department of Urology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-9590","authenticated-orcid":false,"given":"Teemu J.","family":"Murtola","sequence":"additional","affiliation":[{"name":"University of Tampere Faculty of Medicine and Health Technology Tampere Finland"},{"name":"Department of Urology Tampere University Hospital Tampere Finland"},{"name":"Department of Surgery Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"The Finnish Cancer Registry. Statistics of prostate cancer cases in Finland. Available from:https:\/\/cancerregistry.fi"},{"key":"e_1_2_7_3_1","unstructured":"Finnish Current Care Quidelines of Dyslipidaemias. Available from:http:\/\/www.kaypahoito.fi\/web\/english\/guidelineabstracts\/guideline?id=ccs00055"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23273"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt077"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.05.004"},{"key":"e_1_2_7_7_1","first-page":"1689","article-title":"Statin use and mortality of patients with prostate cancer: a meta\u2010analysis","volume":"21","author":"Meng Y","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.8981"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23138"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0096-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-017-0030-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.12"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2442-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1407039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"e_1_2_7_16_1","unstructured":"WHO Collaboration Centre for Drug statistics Methodology. 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