{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:33:25Z","timestamp":1788946405189,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional imaging modalities are inadequate to evaluate locoregional extension of prostate cancer (PCa). The aim of the current retrospective study was to investigate the diagnostic efficacy of Gallium\u201068 prostate\u2010specific membrane antigen\u201011 (Ga\u201068 PSMA\u201011) positron emission tomography\/computed tomography (PET\/CT) and multiparametric magnetic resonance imaging (mp\u2010MRI) for staging preoperative PCa patients with correlating histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010four patients with histologically proven PCa underwent both Ga\u201068 PSMA\u201011 PET\/CT and mp\u2010MRI before robot\u2010assisted laparoscopic radical prostatectomy. For each tumor area, correlations with histopathological results were defined for tumor localization, extraprostatic extension (EPE) of the tumor, invasion of seminal vesicle (SVI) and bladder neck invasion (BNI). In patients with regional lymph node (LN) dissection, histopathological results were also correlated with imaging modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for detection of EPE and SVI were higher for mp\u2010MRI than Ga\u201068 PSMA\u201011 PET\/CT. On the other hand Ga\u201068 PSMA\u201011 PET\/CT had significant successful results for detection of LN metastases when compared with mp\u2010MRI. But for BNI detection both modalities had same insufficient results. Ga\u201068 PSMA\u201011 PET\/CT had strong results for appropriate tumor localization in the gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ga\u201068 PSMA PET\/CT has superior results for assessing local LN metastases and for intraprostatic tumor localization. Whereas, mp\u2010MRI must be the preferred modality for determining SVI and EPE. But both imaging modalities failed for determining BNI accurately. Both modalities should be used in conjunction with each other for better treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23812","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T07:32:04Z","timestamp":1556004724000},"page":"1007-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Comparison of preoperative locoregional Ga\u201068 PSMA\u201011 PET\u2010CT and mp\u2010MRI results with postoperative histopathology of prostate cancer"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-0990","authenticated-orcid":false,"given":"Burcak","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Clinic of Nuclear Medicine, Istanbul Research and Training Hospital Health Sciences University Istanbul 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