{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:18:05Z","timestamp":1761581885585,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul National University Bundang Hospital (SNUBH) Research Fund","award":["03-2013-010"],"award-info":[{"award-number":["03-2013-010"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated prevalence of familial and hereditary prostate cancer (PCa) in Asian population, and compared clinical characteristics between familial and sporadic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pedigrees of 1102 patients who were treated for PCa were prospectively acquired. Clinical and pathologic characteristics and biochemical recurrence (BCR)\u2010free survival were compared between familial PCa and sporadic PCa in patients who underwent radical prostatectomy (RP; <jats:italic>n<\/jats:italic>\u2009=\u2009751).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of familial, first\u2010degree familial, and hereditary PCa was found to be 8.4%, 6.7%, and 0.9%, respectively; similar result was obtained in patients who underwent RP (8.4%, 6.4%, and 0.9%). Patients with familial PCa were significantly younger than those with sporadic PCa (63.3 vs 65.6 years; <jats:italic>P<\/jats:italic>\u2009=\u2009.015). However, preoperative variables (prostate\u2010specific antigen, clinical stage, biopsy Gleason score [GS], and percentage of positive biopsy cores) and postoperative variables (surgical GS, upgrading rate, pathologic stage, and percentage of tumor volume) did not correlate with family history (<jats:italic>P<\/jats:italic> range: .114\u2013.982). Kaplan\u2010Meier analysis of 5\u2010year BCR\u2010free survival revealed no significant difference between sporadic (82.7%), familial (89.4%; <jats:italic>P<\/jats:italic>\u2009=\u2009.594), and first\u2010degree familial (87.1%; <jats:italic>P<\/jats:italic>\u2009=\u2009.774) PCa. Analysis of p53, Bcl\u20102, Ki67, and other immunohistochemistry biomarkers revealed that only increasing p53 expression and first\u2010degree familial PCa approached significance (<jats:italic>P<\/jats:italic>\u2009=\u2009.059).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of familial PCa was somewhat lower in the Asian population than in other ethnic groups. Clinical and pathologic variables and selected histologic biomarker abnormalities were not significantly different in patients with and without a family history of PCa. BCR\u2010free survival following RP was also unaffected by family history.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23917","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T14:55:01Z","timestamp":1572447301000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and pathologic characteristics of familial prostate cancer in Asian population"],"prefix":"10.1002","volume":"80","author":[{"given":"Myong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Urology, Ewha Womans University School of Medicine Ewha Womans University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Kwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhee","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"},{"name":"Department of Urology College of Medicine, Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangchul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-6774","authenticated-orcid":false,"given":"Sung Kyu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"},{"name":"Department of Urology College of Medicine, Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-9035","authenticated-orcid":false,"given":"Seok\u2010Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Urology Bundang Hospital, Seoul National University  Seongnam Republic of Korea"},{"name":"Department of Urology College of Medicine, Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"304","article-title":"Clinico\u2010statistical and genetic research on neoplasms of the prostate","volume":"6","author":"Morganti G","year":"1956","journal-title":"Acta Genet Stat Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35617-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(74)90070-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990060202"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38074-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170409"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04232.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67063-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.7.987"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0036"},{"key":"e_1_2_7_12_1","first-page":"737","article-title":"[Genetic aspects in cancers of the prostate]","volume":"44","author":"Cussenot O","year":"1996","journal-title":"Pathologie\u2010biologie"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970317)70:6<679::AID-IJC9>3.0.CO;2-S"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00103-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117495"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1478"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.969"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67619-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.046"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21391"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.11.095"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3367"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64541-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66705-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00358-X"},{"issue":"5","key":"e_1_2_7_28_1","first-page":"197","article-title":"[Characteristics of hereditary and familial prostate cancer in Japan 2011]","volume":"69","author":"Fukabori Y","year":"2011","journal-title":"Nihon Rinsho"},{"key":"e_1_2_7_29_1","first-page":"5","article-title":"Familial risk factors for prostate cancer","volume":"11","author":"Carter BS","year":"1991","journal-title":"Cancer Surv"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<138::AID-CNCR23>3.0.CO;2-5"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5980\/jpnjurol1989.86.1483"},{"key":"e_1_2_7_32_1","first-page":"35","article-title":"Prostate cancer patients with a positive family history fare worse after surgery","volume":"65","author":"Kupelian P.","year":"1997","journal-title":"Mod Med"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9506-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29041"},{"key":"e_1_2_7_35_1","unstructured":"National Comprehensive Cancer Network. NCCN guidelines version 2. Prostate cancer.2019. Avalable at:https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/346094"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.23917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.23917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.23917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.23917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:24:20Z","timestamp":1694251460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.23917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/pros.23917"],"URL":"https:\/\/doi.org\/10.1002\/pros.23917","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"type":"print","value":"0270-4137"},{"type":"electronic","value":"1097-0045"}],"subject":[],"published":{"date-parts":[[2019,10,30]]},"assertion":[{"value":"2019-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}