{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:23:11Z","timestamp":1768346591411,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["R01CA218144"],"award-info":[{"award-number":["R01CA218144"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Corpora amylacea (CAM), in benign prostatic acini, contain acute\u2010phase proteins. Do CAM coincide with carcinoma?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within 270 biopsies, 83 prostatectomies, and 33 transurethral resections (TURs), CAM absence was designated CAM 0; corpora in less than 5% of benign acini: CAM 1; in 5% to 25%: CAM 2; in more than 25%: CAM 3. CAM were compared against carcinoma presence, clinicopathologic findings, and grade groups (GG) 1 to 2 vs 3 to 5. The frequency of CAM according to anatomic zone was counted. A pilot study was conducted using paired initial benign and repeat biopsies (33 benign, 24 carcinoma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 68.9% of biopsies, 96.4% of prostatectomies, and 66.7% of TURs disclosed CAM. CAM \u22651 was common at an older age (<jats:italic>P<\/jats:italic>\u2009=\u2009.019). In biopsies, 204 cases (75%) had carcinoma; and CAM of 2 to 3 (compared to 0\u20101) were recorded in 25.0% of carcinomas but only 7.4% of benign biopsies (<jats:italic>P<\/jats:italic>\u2009=\u2009.005; odds ratio [OR]\u2009=\u20095.1). CAM correlated with high percent Gleason pattern 3, low GG (<jats:italic>P<\/jats:italic>\u2009=\u2009.035), and chronic inflammation (CI). CI correlated inversely with carcinoma (<jats:italic>P<\/jats:italic>\u2009=\u2009.003). CAM disclosed no association with race, body mass index, serum prostate specific antigen (PSA), acute inflammation (in biopsies), atrophy, or carcinoma volume.<\/jats:p><jats:p>With CAM 1, the odds of GG 3 to 5 carcinoma, by comparison to CAM 0, decreased more than 2\u00d7 (OR\u2009=\u20090.48; <jats:italic>P<\/jats:italic>\u2009=\u2009.032), with CAM 2, more than 3\u00d7 (OR\u2009=\u20090.33; <jats:italic>P<\/jats:italic>\u2009=\u2009.005), and with CAM 3, almost 3\u00d7 (OR\u2009=\u20090.39, <jats:italic>P<\/jats:italic>\u2009=\u2009.086). For men aged less than 65, carcinoma predictive model was: Score\u2009=\u2009(2\u2009\u00d7\u2009age)\u2009+\u2009(5\u2009\u00d7\u2009PSA)\u2009\u2212\u2009(20\u2009\u00d7\u2009degree of CAM); using our data, area under the ROC curve was 78.17%. When the transition zone was involved by cancer, it showed more CAM than in cases where it was uninvolved (<jats:italic>P<\/jats:italic>\u2009=\u2009.012); otherwise zonal distributions were similar.<\/jats:p><jats:p>In the pilot study, CAM \u22651 predicted carcinoma on repeat biopsy (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05; OR\u2009=\u20098), as did CAM 2 to 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; OR\u2009=\u200930). CI was not significant, and CAM retained significance after adjusting for CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CAM correlate with carcinoma. Whether abundant CAM in benign biopsies adds value amidst high clinical suspicion, warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.23980","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T18:04:50Z","timestamp":1586455490000},"page":"687-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low\u2010grade cancer"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-0627","authenticated-orcid":false,"given":"Watchareepohn","family":"Palangmonthip","sequence":"first","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin"},{"name":"Department of Pathology, Faculty of Medicine Chiang Mai University  Chiang Mai 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of Wisconsin  Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Gallan","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-6435","authenticated-orcid":false,"given":"Kenneth A.","family":"Iczkowski","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"104","article-title":"Salient and co\u2010morbid features in benign prostatic hyperplasia: a histopathological study of the prostate","volume":"1","author":"Shakya G","year":"2003","journal-title":"Kathmandu Univ Med J 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