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Senescence and overweight are increasing worldwide and are considered risk factors to prostatic pathogenesis mainly due to oxidative and inflammatory processes induction. Thus, this study aimed to evaluate the effect of two increasing doses of the patented jaboticaba peel extract (PJE) on oxidative\u2010stress and inflammation in the prostate of aging or high\u2010fat\u2010fed aging mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PJE and\/or high\u2010fat diet (HFD) treatments started with 11\u2010month\u2010old mice and lasted 60 days. The levels or the immunoexpression of different inflammatory (nuclear factor \u03baB [NF\u03baB], CD3+, cyclooxygenase 2 [COX\u20102], toll\u2010like receptor 4 [TLR4], phosphorylated signal transducers and activators of transcription 3 [pSTAT\u20103], tumor necrosis factor \u03b1 [TNF\u2010\u03b1], interleukin 6 [IL\u20106], and IL\u20101\u03b2) and oxidative\u2010stress (catalase, superoxide dismutase 2 [SOD2], glutathione reductase [GSR], reduced glutathione, and glutathione peroxidase 3 [GPx3]) related molecules were analyzed by western\u2010blotting, immunohistochemistry, and enzyme\u2010linked immunosorbent assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both PJE doses reduced the levels of oxidative\u2010stress\u2010related molecules (GPx3, GSR, catalase), lipid peroxidation (4\u2010hydroxynonenal), inflammatory mediators (COX\u20102, TNF\u2010\u03b1, and pSTAT\u20103) and CD3+ T cells number, which were associated with the maintenance of the glandular morphological integrity in aging and HFD\u2010fed\u2010aging mice. Nevertheless, only the high PJE dose reduced the NF\u03baB and TLR4 levels in aging mice; and SOD2, IL\u20106, and IL\u20101\u03b2 levels in HFD\u2010aging mice. Aging itself promoted an oxidative inflammation in the prostate, interfering in the levels of the different oxidative\u2010stress, lipid peroxidation, and inflammatory mediators evaluated, in association with high incidence of prostate epithelial and stromal damages. The HFD intake intensified aging alterations, showing an unfavorable prostatic microenvironment prone to oxidative and inflammatory damages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PJE exerted a dose\u2010dependent effect controlling inflammation and oxidative\u2010stress in aging and HFD\u2010fed aging mice prostate. This fact contributed to prostate microenvironment balance recovery, preserving the tissue architecture of this gland. Thus, the PJE emerges as a potential therapy to prevent inflammation and oxidative stress in the prostate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24017","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T21:32:07Z","timestamp":1590615127000},"page":"859-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Brazilian berry extract (<i>Myrciaria jaboticaba<\/i>): A promising therapy to minimize prostatic inflammation and oxidative stress"],"prefix":"10.1002","volume":"80","author":[{"given":"Celina A.","family":"Lamas","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa A.","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology University of Campinas  S\u00e3o Paulo Brazil"},{"name":"Department of Food and Nutrition, School of Food Engineering University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio A.","family":"Hermes","sequence":"additional","affiliation":[{"name":"Department of Morphology and Physiology ABC Medical School Santo Andre S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Nogueira\u2010Lima","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Minatel","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla B.","family":"Collares\u2010Buzato","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"M\u00e1rio R.","family":"Mar\u00f3stica","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, School of Food Engineering University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-7376","authenticated-orcid":false,"given":"Val\u00e9ria\u00a0H. 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