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The aim of this study was to investigate the effect of regular exercise training on the early stages of prostate cancer progression, as well as assessing whether alterations to prostate cancer metabolism are induced by exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice with prostate\u2010specific deletion of <jats:italic>Pten<\/jats:italic> (<jats:italic>Pten<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) remained sedentary or underwent 6 weeks of endurance exercise training or high\u2010intensity exercise training involving treadmill running. At the conclusion of the training period, the prostate lobes were excised. A portion of fresh tissue was used to assess glucose, glutamine, and fatty acid metabolism by radiometric techniques and a second portion was fixed for histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite the implementation of an effective exercise regime, as confirmed by improvements in running capacity, neither prostate mass, cell proliferation or the incidence of high\u2010grade prostate intraepithelial hyperplasia or noninvasive carcinoma in situ were significantly different between groups. Similarly, neither glucose uptake, oxidation and de novo lipogenesis, glutamine oxidation, or fatty acid uptake, oxidation and storage into various lipids were significantly different in prostate tissue obtained from untrained and exercise trained mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results show that 6 weeks of moderate or high\u2010intensity exercise training does not alter substrate metabolism in the prostate or slow the progression of <jats:italic>Pten<\/jats:italic>\u2010null prostate cancer. These results question whether exercise is a useful therapy to prevent or delay prostate cancer progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24024","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T10:31:38Z","timestamp":1591785098000},"page":"906-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early intervention exercise training does not delay prostate cancer progression in <i>Pten<\/i><sup>\u2212\/\u2212<\/sup> mice"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-2380","authenticated-orcid":false,"given":"Renea A.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Physiology, Monash Biomedicine Discovery Institute, Cancer Program Monash University  Clayton Victoria Australia"},{"name":"Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon G.","family":"Farrelly","sequence":"additional","affiliation":[{"name":"Department of Physiology, Monash Biomedicine Discovery Institute, Cancer Program Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee K.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-4188","authenticated-orcid":false,"given":"Matthew J.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"AIHW.Cancer in Australia: An overview 2012. 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