{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:05:35Z","timestamp":1790190335791,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent literature highlights the importance of germline genetic testing in prostate cancer (PCa) patients. Surprisingly, a literature review indicates that family history (FH) records are incomplete in the major published studies from prostate cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective family history data were gathered from 496 men in a single institution with a personal history of PCa who underwent germline genetic testing using a panel of at least 79 genes. Comprehensive first degree FH were obtained in all PCa of patients and analysis of prevalent FH was assessed at the time of sample collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathogenic\/likely pathogenic variants (PV\/LPVs) were not associated with age at diagnosis, race, or presence of metastasis. One or more first degree relatives (FDR) with any cancer was not predictive for germline PV\/LPVs for men with PCa (<jats:italic>p<\/jats:italic>\u2009=\u2009.96). Separate analysis of patients with one or more FDR with breast, prostate, ovarian, or pancreatic cancer revealed that only FDR with breast or ovarian cancer was predictive for PV\/LPVs (<jats:italic>p<\/jats:italic>\u2009=\u2009.028, <jats:italic>p<\/jats:italic>\u2009=\u2009.015 respectively). Patients with a FDR with breast cancer had 1.8 increased risk of PV\/LPVs, and patients with a FDR with ovarian cancer had 2.9 increased risk of PV\/LPV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In men with a personal history of PCa, germline PV\/LPVs were associated with a FDR with breast or ovarian cancer. Notably having FDRs with PCa does not predict for PV\/LPVs. These data emphasize the contribution of FH in a data set with complete ascertainment of FH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24120","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T12:29:27Z","timestamp":1616588967000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Family history and pathogenic\/likely pathogenic germline variants in prostate cancer patients"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-8818","authenticated-orcid":false,"given":"Rachel A.","family":"Sabol","sequence":"first","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-3255","authenticated-orcid":false,"given":"Elisa M.","family":"Ledet","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitley","family":"Hatton","sequence":"additional","affiliation":[{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Lankford","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Zaheria","sequence":"additional","affiliation":[{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Barata","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi L.","family":"Layton","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8777-7343","authenticated-orcid":false,"given":"Oliver","family":"Sartor","sequence":"additional","affiliation":[{"name":"Department of Medicine Tulane University School of Medicine New Orleans Louisiana USA"},{"name":"Department of Urology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Cancer Society. Cancer facts & figures 2020. 2020.https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2020\/cancer-facts-and-figures-2020.pdf"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17703"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1871::AID-CNCR28>3.0.CO;2-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603144"},{"key":"e_1_2_9_6_1","unstructured":"NCC Network. NCCN guidleines version 2.2020 prostate cancer. 2020.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/prostate.pdf"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23739"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2015.04.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23535"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25870"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11030352"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.1173"},{"key":"e_1_2_9_13_1","unstructured":"Highlights of Prescribing Information. FDA. Access date: 4 March 2021.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/208558s014lbl.pdf"},{"key":"e_1_2_9_14_1","unstructured":"Highlights of Prescribing Information. FDA. 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