{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:55:42Z","timestamp":1776531342057,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation plays critical roles at different stages of carcinogenesis and cancer progression. Several previous studies showed conflicting results for the predictive role of systemic inflammation markers in the detection of clinically significant prostate cancers (CSPCs). We aimed to determine the predictive roles of lymphocyte\u2010to\u2010monocyte (LMR) and eosinophil\u2010to\u2010lymphocyte ratios (ELR) in the detection of CSPC at standard 12\u2010core transrectal ultrasound\u2010guided prostate biopsy (12\u2010core\u2010TRUS\u2010Bx) using our large\u2010cohort database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and pathological data of a total of 1740 men, who underwent initial standard 12\u2010core TRUS\u2010Bx, were analyzed. LMR and ELR were calculated from the prebiopsy complete blood count. Definitions of CSPC, LMR, and ELR were \u201cGleason grade group \u22652,\u201d \u201cthe lymphocyte counts\/the monocyte counts,\u201d and \u201cthe eosinophil counts\/the lymphocyte counts,\u201d respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median (interquartile range) of serum prostate\u2010specific antigen\u00a0(PSA) level and prostatic volume before TRUS\u2010Bx were 7.59 (5.02\u201313.12) ng\/ml and 38.2 (29.0\u201352.9) ml, respectively. Benign prostatic lesions, clinically insignificant prostate cancers (CIPCs), and CSPCs were detected in 1179 (67.8%), 180 (10.3%), and 381 (21.9%) patients, respectively. The patients with CSPCs had older age, a higher prevalence of diabetes mellitus or hypertension, a higher rate of digital rectal examination abnormality, higher serum PSA level, lower serum testosterone level, and lower LMR than those with benign lesions or CIPCs. However, there was no difference in ELR among the three (benign lesions, CIPCs and CSPCs). In all the patients, multivariate regression analysis showed that lower LMR was an independent predictor of CSPCs compared with ELR. In the subset of men with prostate volume \u226539.3\u2009ml, lower LMR was an independent predictor of CSPCs compared with ELR. In the subset of men with prostate volume &lt;39.3\u2009ml, men with lower LMR showed the tendency of having a higher probability of CSPCs without any statistical significance on the contrary to ELR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that LMR can play an independent predictive role in the detection of CSPCs at initial 12\u2010core\u2010TRUS\u2010Bx compared with ELR. The predictive role of the LMR appears to be significant for men with larger prostate volume rather than those with smaller prostate volume.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24222","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T19:39:27Z","timestamp":1631561967000},"page":"1278-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lymphocyte\u2010to\u2010monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-1706","authenticated-orcid":false,"given":"Min Chul","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Urology Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Urology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-7053","authenticated-orcid":false,"given":"Sangjun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Urology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Soo","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Urology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-0153","authenticated-orcid":false,"given":"Hwancheol","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Urology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-1402","authenticated-orcid":false,"given":"Hyeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Urology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810084"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071637"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002526"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2019.12.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.11.3385"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.576812"},{"key":"e_1_2_9_13_1","first-page":"11746","article-title":"Platelet to lymphocyte ratio plays an important role in prostate cancer's diagnosis and prognosis","volume":"8","author":"Li F","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13206"},{"key":"e_1_2_9_15_1","unstructured":"WHO WesternPacific Region IASO IOTF: The Asia\u2010Pacific Perspective: Redefining Obesity and Its Treatment. Health Communications Australia Pty Limit Sydney Australia 2000."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.4.655.655"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-16-0209"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.11.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13801"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2020.19203"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2018.4.270"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74703-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_19_20"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34025-4_9"},{"key":"e_1_2_9_26_1","first-page":"308","article-title":"Monocyte\u2010induced prostate cancer cell invasion is mediated by chemokine ligand 2 and nuclear factor\u2010\u03baB activity","volume":"6","author":"Lindholm PF","year":"2015","journal-title":"J Clin Cell Immunol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1300"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-006-9078-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0283-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494259"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.24222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:00:39Z","timestamp":1693224039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":29,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/pros.24222"],"URL":"https:\/\/doi.org\/10.1002\/pros.24222","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"2021-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}