{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:09Z","timestamp":1792028709229,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Clinician Scientist Program ME3696\/3\u20101 (R.A.W.)"],"award-info":[{"award-number":["Clinician Scientist Program ME3696\/3\u20101 (R.A.W.)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate\u2010specific membrane antigen (PSMA)\u2010targeted radioligand therapy (RLT) may be associated with renal toxicity. We aimed to identify predictive parameters for the development of chronic kidney disease (CKD) in patients with metastatic castration resistant prostate cancer (mCRPC) undergoing RLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 46 mCRPC patients scheduled for Lu\u2010177\u2010PSMA\u2010RLT, pretherapeutic estimated glomerular filtration rate (eGFR [ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>]), Tc\u201099m\u2010mercaptoacetyltriglycine (Tc\u201099m\u2010MAG3) clearance and baseline Ga\u201068\u2010PSMA\u2010ligand positron emission tomography (PET)\u2010derived renal cortical uptake and PSMA\u2010tumor volume (TV) were determined. We tested the predictive capability of these parameters and clinical risk factors for the occurrence of CKD (defined as CTCAE vers. 5.0 grade 2 or higher) during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 4\u2009\u00b1\u20093 cycles of RLT average eGFR declined from 76\u2009\u00b1\u200917 to 72\u2009\u00b1\u200920\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>(<jats:italic>p<\/jats:italic>\u2009=\u20090.003). Increased estimated renal radiation dose (eRRD) was significantly associated with renal functional decline (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). During follow\u2010up, 16\/46 (30.4%) developed CKD grade 2 (no grade 3 or higher). In receiver operating characteristic (ROC) analysis, pretherapeutic eGFR was highly accurate in identifying the occurrence of CKD vs no CKD with an area under the curve (AUC) of 0.945 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; best threshold, 77\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>), followed by Tc\u201099m\u2010MAG3\u2010derived tubular extraction rate (TER; AUC, 0.831,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; best threshold, 200\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>). Renal PET signal (<jats:italic>p<\/jats:italic>\u2009=\u20090.751) and PSMA\u2010TV (<jats:italic>p<\/jats:italic>\u2009=\u20090.942), however, were not predictive. Kaplan\u2013Meier analyses revealed adverse renal outcome for patients with lower eGFR (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and lower scintigraphy\u2010derived TER (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), with pretherapeutic eGFR emerging as the sole predictive parameter in multivariate analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serious adverse renal events are not a frequent phenomenon after PSMA\u2010targeted RLT. However, in patients developing moderate CKD after RLT, pretherapeutic eGFR is an independent predictor for renal impairment during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24250","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T13:21:56Z","timestamp":1634217716000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pretherapeutic estimated glomerular filtration rate predicts development of chronic kidney disease in patients receiving PSMA\u2010targeted radioligand therapy"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-9338","authenticated-orcid":false,"given":"Liam","family":"Widjaja","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8786-4105","authenticated-orcid":false,"given":"Thorsten","family":"Derlin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias L.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Bengel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2019.07.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1050"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47251"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23974"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.241588"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.183194"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.227"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04485-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30198-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00237-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262441"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"81","article-title":"Prostate\u2010specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"Silver DA","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.178483"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3174-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3125-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/935351"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3681-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.234898"},{"issue":"5","key":"e_1_2_10_22_1","first-page":"249","article-title":"Determination of split renal function by PSMA imaging: comparison of (68)ga\u2010PSMA\u201011 PET with (99m)tc\u2010MAG3 scintigraphy","volume":"10","author":"Rosar F","year":"2020","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"12","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.2460\/ajvr.1994.55.12.1652","article-title":"Evaluation of the single\u2010injection plasma disappearance of technetium\u201099m mercaptoacetyltriglycine method for determination of effective renal plasma flow in dogs with normal or abnormal renal function","volume":"55","author":"Itkin RJ","year":"1994","journal-title":"Am J Vet Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.12.2239"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04359-8"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.236414"},{"key":"e_1_2_10_27_1","article-title":"Tumor sink effect in 68Ga\u2010PSMA\u201011 PET: Myth or reality? [published online ahead of print May 28, 2021]","author":"Gafita A","journal-title":"J Nucl Med"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9775"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122938"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05412-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185857"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001589"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.193581"},{"key":"e_1_2_10_34_1","unstructured":"U.S. Department Of Health and Human Services.\u00a0Common terminology criteria for adverse events (CTCAE) (version 5.0); 2020. Accessed December 3.https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_5x7.pdf"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200410135"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0209"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4044-x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.193706"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.170167"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3001-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.133447"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37894"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.219352"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.218917"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191395"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.12.006"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.03.004"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.24250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T23:19:00Z","timestamp":1725923940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/pros.24250"],"URL":"https:\/\/doi.org\/10.1002\/pros.24250","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"2021-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}