{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:20:44Z","timestamp":1769743244806,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Smaller prostates have been linked to unfavorable clinical characteristics and poor short\u2010term outcomes following radical prostatectomy (RP). We examined the relation between prostate weight at RP and prostate cancer (PC) outcomes post\u2010RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Men in the SEARCH cohort undergoing RP between 1988 and 2017 (<jats:italic>N<\/jats:italic>\u2009=\u20096242) were studied for PC\u2010specific mortality (PCSM) as the primary outcome, and for biochemical recurrence (BCR), castration\u2010resistant PC (CRPC) and metastasis as secondary outcomes. Hazard ratios (HR) and 95% confidence intervals (CI) were determined for associations between prostate weight and outcomes using Fine\u2010Gray competing risk regression multivariable analyses. Sensitivity analyses were also carried out following exclusion of: (i) men with extreme prostate weights (&lt;20\u2009g and \u2265100\u2009g); and (ii) men with elevated prostate specific antigen (PSA) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median values for age, pre\u2010RP PSA and prostate weight were 63 years, 6.6\u2009ng\/ml, and 42.0\u2009g, respectively. During a median follow\u2010up of 7.9 years, 153 (3%) died from PC, 2103 (34%) had BCR, 203 (3%) developed CRPC, and 289 (5%) developed metastases. Prostate weight was not associated with PCSM in the main analyses (multivariable HR\u2009=\u20091.43; 95% CI: 0.87\u20132.34) or in sensitivity analyses. Prostate weight was inversely associated with BCR in the main analyses (multivariable HR\u2009=\u20090.70; 95%CI: 0.61\u20130.79) which was unchanged in sensitivity analyses. HRs for prostate weight and CRPC and metastasis were elevated but statistical significance was not attained. Similar results were observed in sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inconsistent results for prostate weight and short\u2010term vs longer\u2010term outcomes highlight the need to better understand the complex biology leading to prostate size and the relevance of prostate size as a predictor of PC outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24283","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T18:05:11Z","timestamp":1639505111000},"page":"366-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prostate weight and prostate cancer outcomes after radical prostatectomy: Results from the SEARCH cohort study"],"prefix":"10.1002","volume":"82","author":[{"given":"Sean Kennedy","family":"Barlow","sequence":"first","affiliation":[{"name":"Division of Urology Durham Veterans Affairs Health Care System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taofik","family":"Oyekunle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke Cancer Institute Biostatistics Shared Resource Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Janes","sequence":"additional","affiliation":[{"name":"Division of Urology Durham Veterans Affairs Health Care System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"De Hoedt","sequence":"additional","affiliation":[{"name":"Division of Urology Durham Veterans Affairs Health Care System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Aronson","sequence":"additional","affiliation":[{"name":"Department of Urology University of California Los Angeles Medical Center  Los Angeles California USA"},{"name":"Division of Urology Wadsworth Veterans Affairs Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Diego Health System  San Diego California USA"},{"name":"Division of Urology Veterans Affairs San Diego Healthcare System  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Urology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Cooperberg","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco Medical Center  San Francisco California USA"},{"name":"Division of Urology San Francisco Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary W.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Surgery Augusta University  Augusta Georgia USA"},{"name":"Division of Urology Charlie Norwood Veterans Affairs Medical Center  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha K.","family":"Terris","sequence":"additional","affiliation":[{"name":"Department of Surgery Augusta University  Augusta Georgia USA"},{"name":"Division of Urology Charlie Norwood Veterans Affairs Medical Center  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-6419","authenticated-orcid":false,"given":"Stephen J","family":"Freedland","sequence":"additional","affiliation":[{"name":"Division of Urology Durham Veterans Affairs Health Care System  Durham North Carolina USA"},{"name":"Department of Surgery Cedars\u2010Sinai Medical Center  Los Angeles Los Angeles USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-1310","authenticated-orcid":false,"given":"Ilona","family":"Csizmadi","sequence":"additional","affiliation":[{"name":"Department of Surgery Cedars\u2010Sinai Medical Center  Los Angeles Los Angeles USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.525"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.04.082"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09182.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12748"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410312911806"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175874"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21318"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.03.033"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2011.05.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00031-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0448"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(02)80307-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30071"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.03.088"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm323"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.8648"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1210"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000062674.43964.d0"},{"issue":"384","key":"e_1_2_8_23_1","first-page":"e21","article-title":"Low circulating free and bioavailable testosterone levels as predictors of high\u2010grade tumors in patients undergoing radical prostatectomy for localized prostate cancer","volume":"33","author":"L\u00e9on P","year":"2015","journal-title":"Urol Oncol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00619-X"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.7.463"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.969"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0434-4"},{"key":"e_1_2_8_28_1","first-page":"77","article-title":"Histological changes of the peripheral zone in small and large prostates and possible clinical implications","volume":"11","author":"Guzman JA","year":"2019","journal-title":"Res Rep Urol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.0247"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000035544.25483.61"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.032"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00647-X"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.24283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:51:32Z","timestamp":1692957092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/pros.24283"],"URL":"https:\/\/doi.org\/10.1002\/pros.24283","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"assertion":[{"value":"2021-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}