{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:58:00Z","timestamp":1792043880469,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High\u2010intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL\u20102, BAX, IGF\u20101, FAS\/CD95, data's inflammatory tumour necrosis factor \u03b1, nuclear factor kappa B and interleukin (IL)\u20106, anti\u2010inflammatory IL\u201010. The echocardiographic evaluation was performed at the baseline and after the training period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF\u20101, BCL\u20102 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and inflammatory proteins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Eight weeks of HIIT training reduced the arterial pressure and increase the concentration of tissue collagen and intracellular glycogen and showed a higher expression of BAX, FAS\/CD95, and IL\u201010 proteins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), coinciding with a lower incidence of lesions and lower prostate weight (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and reduction of the BCL\u20102 and IGF\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggested that arterial hypertension suppressed apoptosis and increased damage prostatic. On other hand, HIIT promotes morphology and function improves in the prostatic environment, inhibited inflammation, and increased apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24285","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T18:00:17Z","timestamp":1639504817000},"page":"373-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High\u2010intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-7043","authenticated-orcid":false,"given":"Rafael Ribeiro","family":"Correia","sequence":"first","affiliation":[{"name":"Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences S\u00e3o Paulo State University (UNESP) Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-4297","authenticated-orcid":false,"given":"Victor Rog\u00e9rio Garcia","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences S\u00e3o Paulo State University (UNESP) Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-8113","authenticated-orcid":false,"given":"Allice Santos Cruz","family":"Veras","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences S\u00e3o Paulo State University (UNESP) Presidente Prudente S\u00e3o Paulo Brazil"},{"name":"Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Ara\u00e7atuba S\u00e3o Paulo State University (UNESP) Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-2840","authenticated-orcid":false,"given":"Maria Eduarda de Almeida","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences S\u00e3o Paulo State University (UNESP) Presidente Prudente S\u00e3o Paulo Brazil"},{"name":"Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Ara\u00e7atuba S\u00e3o Paulo State University (UNESP) Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francilene Lima Agostinho","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Animal Science Program University of Western S\u00e3o Paulo (UNOESTE) Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5854","authenticated-orcid":false,"given":"Francis Lopes","family":"Pacagnelli","sequence":"additional","affiliation":[{"name":"Postgraduate Animal Science Program University of Western S\u00e3o Paulo (UNOESTE) Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4933-0604","authenticated-orcid":false,"given":"Dijon Henrique Salom\u00e9","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Botucatu Medical School S\u00e3o Paulo State University Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-8374","authenticated-orcid":false,"given":"Ines Cristina","family":"Giometti","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Faculty of Agricultural Sciences University of Western S\u00e3o Paulo (UNOESTE) Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-2939","authenticated-orcid":false,"given":"Giovana Rampazzo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences S\u00e3o Paulo State University (UNESP) Presidente Prudente S\u00e3o Paulo Brazil"},{"name":"Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Ara\u00e7atuba S\u00e3o Paulo State University (UNESP) Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-018-0716-z"},{"key":"e_1_2_10_3_1","unstructured":"INCA.Cancer statistics.2020. 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