{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:05:06Z","timestamp":1773738306995,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histopathological characteristics affecting the detectability of clinically significant prostate cancer (csPCa) on magnetic resonance imaging (MRI) remain unclear. This study aimed to compare the histopathology between MRI\u2010detectable and MRI\u2010undetectable cancers, emphasizing intraductal carcinoma of the prostate (IDC\u2010P) and predominant Gleason pattern 4 subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study enrolled 153 consecutive patients with 191 lesions who underwent preoperative multiparametric MRI\u00a0and subsequent radical prostatectomy. MRI\/histopathological findings and area fractions of histological components (cancer cells, stroma, and luminal spaces) of MRI\u2010detectable and MRI\u2010undetectable cancers were compared. Data were analyzed using Fisher's exact, independent <jats:italic>t<\/jats:italic>, or Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 148 (77%) and 43 (23%) cancers were MRI\u2010detectable and MRI\u2010undetectable, respectively. MRI\u2010detectable cancers were significantly larger than MRI\u2010undetectable cancers (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). The percentage of lesions in Grade Group 3 or higher was significantly higher among MRI\u2010detectable cancers than among MRI\u2010undetectable cancers (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). MRI detectability of csPCa was associated with increases in relative area fractions of cancer cells (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and decreases in those of stroma (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and luminal spaces (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in prostate cancer (PCa) than the percentage of Gleason pattern 4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.09). The percentage of lesions containing IDC\u2010P was similar for MRI\u2010detectable and MRI\u2010undetectable cancers (40% vs. 33%; <jats:italic>p<\/jats:italic>\u2009=\u20090.48). The distribution of cribriform gland subtypes was not significantly different between MRI\u2010detectable and MRI\u2010undetectable Gleason pattern 4 subtype cancers (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.99). Contrarily, the ratio of fused gland subtype was significantly higher in MRI\u2010detectable than in MRI\u2010undetectable cancers (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Furthermore, the ratio of poorly\u2010formed gland subtype was significantly higher in MRI\u2010undetectable than in MRI\u2010detectable cancers (<jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MRI detectability of csPCa is strongly associated with the relative area fractions of cancer cells, stroma, and luminal spaces in PCa rather than conventional histopathological parameters. Neither the presence nor the percentage of IDC\u2010P affected MRI detectability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24291","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T04:59:09Z","timestamp":1640753949000},"page":"452-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["MRI\u2010detectability and histological factors of prostate cancer including intraductal carcinoma and cribriform pattern"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-3823","authenticated-orcid":false,"given":"Ayako","family":"Mikoshi","sequence":"first","affiliation":[{"name":"Department of Radiology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Miyai","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology National Defense Medical College Tokorozawa Saitama Japan"},{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Hamabe","sequence":"additional","affiliation":[{"name":"Department of Radiology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Edo","sequence":"additional","affiliation":[{"name":"Department of Radiology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shinmoto","sequence":"additional","affiliation":[{"name":"Department of Radiology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019182946"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.01.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14420"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2019.03.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1823-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.03.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.04.029"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.01.077"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.07.037"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14812"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26594"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.01.081"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0292-y"},{"key":"e_1_2_10_17_1","unstructured":"American College of Radiology European Society of Urogenital Radiology AdMe Tech Foundation. 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