{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:04:54Z","timestamp":1775027094399,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imaging modalities are used to diagnose and clinical grading of clinically significant prostate cancer. In this study, 68Ga\u2010PSMA PET\/CT (PSMA) and multiparametric prostate MRI (mp\u2010MRI) were compared in regard to locating intraprostatic tumor and locoregional staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After ethics committee approval, a total of 49 patients with prostate cancer who had mp\u2010MRI and PSMA before radical prostatectomy were included. Preoperative and postoperative PSA, transrectal ultrasound\u2010guided prostate biopsy (TRUS\u2010Bx) ISUP grade, radical prostatectomy ISUP grade, body mass index (BMI), TRUS prostate volume, mp\u2010MRI tumor mapping, PSMAtumor mapping, pathologic tumor mapping, extraprostatic extension (EPE), seminal vesicle invasion (SVI), lymph node invasion (LNI), and bladder neck invasion (BNI)were retrospectively evaluated. Index tumor was located by uroradiologist, nuclear medicine specialist, and uropathologist on a 12\u2010sector prostate pathology map and compared with each other in terms of accuracy and locoregional clinical staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of the patients was 66.18\u2009\u00b1\u20096.67 years and the mean of preoperative PSA results was 21.11\u2009\u00b1\u200932.56\u2009ng\/ml. Nearly half of the patients' (44.9%) pathology was reported as ISUP grade 4 and 5% and 18.4% of patients were surgical margin positive. According to the pathological findings, 362 out of 588 sectors were tumor\u2010positive, 174 out of 362 sectors were tumor\u2010positive in mp\u2010MRI, and 175 out of 362 sectors were tumor\u2010positive in PSMA. Both PSMA and mp\u2010MRI were comparable (<jats:italic>p<\/jats:italic>\u2009=\u20090.823) and accurate to detect the location of the intraprostatic index tumor (AUC\u2009=\u20090.66 vs. 0.69 respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.82). The sensitivity and the specificity of the PSMA and mp\u2010MRI for localizing intraprostatic index tumors were 42.5% versus 49.5% and 90.7% versus 88.6% respectively. mp\u2010MRI was more accurate than PSMA in terms of EPE (AUC\u2009=\u20090.8 vs. AUC\u2009=\u20090.57 respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.027) and both methods were comparable in terms of SVI (AUC\u2009=\u20090.75 vs. AUC\u2009=\u20090.75, <jats:italic>p<\/jats:italic>\u2009=\u20090.886) and BNI (AUC\u2009=\u20090.51 vs. AUC\u2009=\u20090.59, <jats:italic>p<\/jats:italic>\u2009=\u20090.597). PSMA and mp\u2010MRI were comparable in terms of LNI (AUC\u2009=\u20090.76 vs. AUC\u2009=\u20090.64, <jats:italic>p<\/jats:italic>\u2009=\u20090.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>mp\u2010MRI should be considered for its high accuracy in the diagnosis of EPE, especially before decision\u2010making for nerve\u2010sparing surgery in high\u2010risk patients. Both imaging modalities were accurate for localizing intraprostatic index tumor. PSMA is accurate for detecting LNI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24420","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T05:24:32Z","timestamp":1659417872000},"page":"1462-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of 68Ga\u2010PSMA PET\/CT and mp\u2010MRI in regard to local staging for prostate cancer with histopathological results: A retrospective study"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7684-3632","authenticated-orcid":false,"given":"Taha","family":"Ucar","sequence":"first","affiliation":[{"name":"Department of Urology Nigde Omer Halis Demir University Research and Training Hospital  Nigde Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Radiology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yeditepe University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-1192","authenticated-orcid":false,"given":"Meftun","family":"Culpan","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humeyra","family":"Gunel","sequence":"additional","affiliation":[{"name":"Department of Pathology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gozde","family":"Kir","sequence":"additional","affiliation":[{"name":"Department of Pathology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan Gokhan","family":"Atis","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-019-00730-z"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"81","article-title":"Prostate\u2010specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"Silver DA","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-008-9104-2"},{"key":"e_1_2_7_5_1","volume-title":"EAU\u2212ESTRO\u2212ESUR\u2212SIOG Guidelines on Prostate Cancer 2020. European Association of Urology Guidelines 2020 Edition. presented at the EAU Annual Congress Amsterdam 2020","author":"Mottet N","year":"2020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2017.05.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02574-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.189233"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.169243"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.221010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23812"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2015.15099"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.178"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.24420","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:17:32Z","timestamp":1692717452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":14,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/pros.24420"],"URL":"https:\/\/doi.org\/10.1002\/pros.24420","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2022-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}