{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:52Z","timestamp":1786978492017,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare long\u2010term outcomes of radical prostatectomy (RP) and low\u2010dose\u2010rate brachytherapy (LDR\u2010BT) using propensity score\u2010matched analysis in patients with clinically localized, intermediate\u2010risk prostate cancer (PCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between October 2003 and March 2014, our institution treated 1241 patients with intermediate\u2010risk PCa (RP:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009531; LDR\u2010BT:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009710). Biochemical recurrence (BCR) was defined as prostate\u2010specific antigen (PSA) levels of 0.2\u2009ng\/ml or greater for RP, and as PSA nadir plus 2\u2009ng\/ml or higher (Phoenix definition) for LDR\u2010BT. We calculated propensity scores by multivariate logistic regression based on covariates that included age, pretreatment PSA, biopsy Gleason grade, the percentage of positive biopsy cores (PPBC), and clinical T stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 108 months for RP and 99 months for LDR\u2010BT. After propensity score adjustment, a total of 642 (321 each) patients remained for further analysis. Kaplan\u2013Meier curves showed no statistically significant difference in overall survival (OS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99). LDR\u2010BT was associated with improved BCR\u2010free survival and salvage therapy\u2010free survival \u00a0compared to RP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and RP was associated with improved metastasis\u2010free survival (MFS,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BCR cannot be a surrogate for survival comparison, primarily due to differences between treatment modalities in how this term was defined post\u2010therapy. Long\u2010term follow\u2010up showed that RP was associated with lower MFS in intermediate\u2010risk PCa. However, this has not yet translated into superior OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.24445","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:10:06Z","timestamp":1664496606000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term outcomes of radical prostatectomy versus low\u2010dose\u2010rate brachytherapy in patients with intermediate\u2010risk prostate cancer: Propensity score matched comparison"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-8183","authenticated-orcid":false,"given":"Fumihiko","family":"Urabe","sequence":"first","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9923","authenticated-orcid":false,"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Iwatani","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tsusumi","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midoriko","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Minato","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Egawa","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.42"},{"key":"e_1_2_10_4_1","unstructured":"National Comprehensive Cancer Network Prostate Cancer (version 3). 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