{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:26:18Z","timestamp":1780345578586,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H05556"],"award-info":[{"award-number":["19H05556"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09517"],"award-info":[{"award-number":["20K09517"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to evaluate the effects of apalutamide dose reduction on skin\u2010related adverse events (AEs) and castration\u2010resistant prostate cancer (CRPC)\u2010free survival in patients with advanced prostate cancer (PC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 35 patients with nonmetastatic CRPC and 72 patients with treatment\u2010na\u00efve metastatic castration\u2010sensitive PC (mCSPC) who were treated with apalutamide. The primary outcome was the effect of apalutamide dose reduction on skin\u2010related AEs. The secondary outcomes were the effect of apalutamide dose reduction on skin\u2010related AEs in patients with small body size, postskin AE apalutamide discontinuation rate, and CRPC\u2010free survival in patients with mCSPC treated with upfront apalutamide plus androgen deprivation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 107 patients, 65 (60.7%) and 42 (39.3%) were treated with full and reduced doses of apalutamide, respectively. The skin\u2010related AE rate was not significantly different between the groups (55% vs. 43%, <jats:italic>p<\/jats:italic>\u2009=\u20090.761). In the group receiving reduced apalutamide dose, the incidence of skin\u2010related AEs was significantly lower in patients with small body sizes (body weight &lt;67\u2009kg and body mass index &lt;24\u2009kg\/m<jats:sup>2<\/jats:sup>) than in those with other body sizes. The postskin AE apalutamide discontinuation rate was significantly differed between patients receiving the full (50%) and reduced (16.7%) doses. In the 72 patients with mCSPC, CRPC\u2010free survival was not significantly different between the full and reduced dose groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Apalutamide dose reduction was not significantly associated with the incidence of skin\u2010related AEs. However, dose reduction in patients with small body sizes may alleviate skin\u2010related AEs without sacrificing oncological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24453","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:13:48Z","timestamp":1667207628000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of apalutamide dose reduction on skin\u2010related adverse events in patients with advanced prostate cancer: A multicenter retrospective study"],"prefix":"10.1002","volume":"83","author":[{"given":"Takuya","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine Hirosaki 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