{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:16:02Z","timestamp":1790795762114,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate staging and identification of optimal candidates for local salvage therapy, such as salvage radical prostatectomy (SRP), is necessary to ensure optimal care in patients with radiorecurrent prostate cancer (PCa). We aimed to analyze performance of magnetic resonance imaging (MRI) and prostate\u2010specific membrane antigen (PSMA)\u2010positron emission tomography (PET)\/computed tomography (CT) for predicting pathologic nonorgan confined disease (pT3) and lymph node involvement (pN+) in patients treated with SRP for radiorecurrent PCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the institutional database to identify patients who underwent MRI or <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u2010PET\/CT before SRP for radiorecurrent PCa. The diagnostic estimates of MRI and PSMA\u2010PET\/CT for pT3 and pN+, were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 113 patients with radiorecurrent PCa who underwent preoperative MRI followed by SRP; 53 had preoperative <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u2010PET\/CT. For the detection of pT3 disease, the overall accuracy of MRI was 70% (95% confidence interval [CI] 61\u221278), sensitivity 40% (95%\u00a0CI 26\u221255) and specificity 94% (95%\u00a0CI 85\u221298); PSMA\u2010PET\/CT had slightly higher accuracy of 77% (95%\u00a0CI 64\u221288), and higher sensitivity of 90% (95%\u00a0CI 68\u221299), but lower specificity of 70% (95%\u00a0CI 51\u221284). For pN+ disease, MRI had poor sensitivity of 14% (95%\u00a0CI 3\u221236), specificity of 50 (95% CI 39\u221261) and total accuracy of 43% (95%\u00a0CI 34\u221253); PSMA\u2010PET\/CT had an accuracy of 85% (95%\u00a0CI 72\u221293), sensitivity of 27% (95%\u00a0CI 6\u221261), and specificity of 100% (95%\u00a0CI 92\u2212100).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with radiorecurrent PCa, both, MRI, and <jats:sup>68<\/jats:sup>Ga\u2010PSMA PET\/CT are valuable tools for the pre\u2010SRP staging and should be integrated into the standard workup. For lymph node metastases, <jats:sup>68<\/jats:sup>Ga\u2010PSMA PET\/CT is a strong rule\u2010in test with nearly perfect specificity; in contrast MRI had a low accuracy for lymph node metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24470","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T06:30:31Z","timestamp":1671863431000},"page":"385-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Importance of magnetic resonance imaging and prostate\u2010specific membrane antigen PET\u2010CT in patients treated with salvage radical prostatectomy for radiorecurrent prostate cancer"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-6584","authenticated-orcid":false,"given":"Pawel","family":"Rajwa","sequence":"first","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology Medical University of Silesia  Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Specialized Urologic Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Specialized Urologic Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Specialized Urologic Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Persigehl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology, Second Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"},{"name":"Department of Urology Weill Cornell Medical College  New York New York USA"},{"name":"Department of Urology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Specialized Urologic Surgery University Hospital Cologne  Cologne 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