{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T21:58:49Z","timestamp":1787522329278,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to assess the oncologic efficacy of combining docetaxel (DOC) versus abiraterone (ABI) with androgen deprivation therapy (ADT) in patients with high\u2010risk metastatic hormone\u2010sensitive prostate cancer (mHSPC), with a focus on the efficacy of sequential therapy, in a real\u2010world clinical practice setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The records of 336 patients who harbored de novo high\u2010risk mHSPC, based on the LATITUDE criteria, and had received ADT with either DOC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) or ABI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009227) were retrospectively analyzed. Overall survival (OS), cancer\u2010specific survival (CSS), progression\u2010free survival (PFS), including time to castration\u2010resistant prostate cancer (CRPC), time to 2nd\u2010line progression (PFS2), and 2nd\u2010 and 3rd\u2010line PFS, were compared. We used one\u2010to\u2010two propensity score matching to minimize the confounders. The differential efficacy of 2nd\u2010line therapy based on agents in each arm was evaluated using the unmatched cohort as an additional interest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score matching, 86 patients treated with DOC\u2009+\u2009ADT and 172 with ABI\u2009+\u2009ADT were available for analyses. The 3\u2010year OS and CSS for DOC versus ABI were 76.2% versus 75.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8) and 78.2% versus 78.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091), respectively. There was no difference in the median PFS2 (49 vs. 43 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39), while the median time to CRPC in patients treated with ABI was significantly longer compared to those treated with DOC (42 vs. 22 months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). The median 2nd\u2010line\u00a0PFS (14 vs. 4 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 3rd\u2010line\u00a0PFS (4 vs. 2 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) were significantly better in the DOC group than in the ABI group. Among the unmatched cohort, after ABI for mHSPC, the median 2nd\u2010line\u00a0PFS did not differ between the patients treated with DOC and those treated with enzalutamide as 2nd\u2010line therapy (both 3 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADT with DOC or ABI has comparable oncologic outcomes in terms of OS, CSS, and PFS2 in patients with de novo high\u2010risk mHSPC. Compared to DOC, ABI resulted in longer time to CRPC but worse 2nd and 3rd\u2010line PFS. Further studies are needed to clarify the optimal sequence of therapy in the upfront intensive treatment era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.24488","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T05:24:07Z","timestamp":1674192247000},"page":"563-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Docetaxel versus abiraterone for metastatic hormone\u2010sensitive prostate cancer with focus on efficacy of sequential therapy"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-0712","authenticated-orcid":false,"given":"Takafumi","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"},{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna Vienna 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