{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:16:39Z","timestamp":1783206999744,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A prognostic risk score (Halabi score) in metastatic castration\u2010resistant prostate cancer (mCRPC) accurately predicts overall survival, but its association with quality of life (QOL) has not been defined. We hypothesize that a higher pretreatment Halabi score is associated with worse QOL outcomes over time in mCRPC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient\u2010level data from the docetaxel plus prednisone control arm of Mainsail, a Phase 3 clinical trial in mCRPC were accessed via ProjectDataSphere. Pretreatment Halabi score included disease\u2010related factors: metastatic site, opioid use, Eastern Cooperative Oncology Group performance status (ECOG\u2010PS), alkaline phosphatase, albumin, hemoglobin, lactic acid dehydrogenase, and PSA, with higher score indicating worse survival. Three QOL scales were created: Functional Assessment of Cancer Therapy\u2010Prostate (FACT\u2010P, higher score\u2009=\u2009better QOL), Brief Pain Inventory\u2010Short Form Severity score (BPI\u2010SFSS, higher score\u2009=\u2009higher pain severity), and BPI\u2010SF Interference score (BPI\u2010SFIS, higher score\u2009=\u2009greater pain interference). Mixed linear model was used to estimate the associations between Halabi score and QOL scores assessed at different time points (baseline, 2 months, and 6 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis included 412 mCRPC patients (median age\u2009=\u200968 years, 82% white, 5% Black, median log PSA\u2009=\u20094.4\u2009ng\/mL). After multivariable adjustment, Halabi score was significantly associated with QOL scores at all time points. At 6 months, multivariable adjusted FACT\u2010P decreased by 10.0 points (worsening), BPI\u2010SFSS increased by 0.8 points (worsening), and BPI\u2010SFIS increased by 0.9 points (worsening) for each unit increase in Halabi risk score. In multivariable analysis of individual components, ECOG\u2010PS, site of metastasis, and opioid use were significantly associated with worse QOL scores at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chemotherapy\u2010na\u00efve mCRPC patients with poorer Halabi prognostic risk scores have poorer QOL and greater pain intensity and interference at baseline and during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24503","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T18:39:05Z","timestamp":1677436745000},"page":"688-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life outcomes for patients with metastatic castration\u2010resistant prostate cancer and pretreatment prognostic score"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8106-0483","authenticated-orcid":false,"given":"Mosunmoluwa","family":"Oyenuga","sequence":"first","affiliation":[{"name":"Department of Internal Medicine SSM St Mary's Hospital St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Halabi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abayomi","family":"Oyenuga","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"McSweeney","sequence":"additional","affiliation":[{"name":"Department of Urology Cleveland Clinic Cleveland Ohio 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