{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:20:58Z","timestamp":1790806858537,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the treatment outcomes and toxicity of definitive radiotherapy (RT)\u00a0for prostate cancer (PC)\u00a0patients using the simultaneous integrated boost (SIB)\u00a0technique, which delivered 78\u2009Gy to the entire prostate and 86\u2009Gy to the intraprostatic lesion (IPL)\u00a0in 39 fractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Univariable and multivariable analyses were conducted of the prognostic factors for freedom from biochemical failure (FFBF),\u00a0progression\u2010free survival (PFS),\u00a0and PC\u2010specific survival (PCSS)\u00a0of 619 PC patients who received definitive RT between September 2012 and August 2021. Predictors of late Grade \u22652 genitourinary (GU)\u00a0and gastrointestinal (GI)\u00a0toxicities were also identified using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up for entire cohort was 68.5 months. The 5\u2010year FFBF, PFS, and PCSS rates were 93.2%, 83.2%, and 98.6%, respectively. They were predicted by the serum prostate\u2010specific antigen,\u00a0Gleason score (GS),\u00a0clinical nodal stage, and D'Amico risk group. Only 45 patients (7.3%) developed disease recurrence 41.9 months after RT. The 5\u2010year FFBF rates for low\u2010, intermediate\u2010, and high\u2010risk disease were 98.0%, 93.1%, and 88.5%, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 5\u2010year PFS and PCSS rates according to risk groups were 91.0%, 82.1%, and 77.4% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 99.2%, 96.4%, and 95.9% (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), and, respectively. GS\u2009&gt;\u20097 and lymph node metastasis negatively predicted FFBF and PCSS in multivariable analysis. Ninety (14.6%) and 44 (7.1%) patients had acute Grade \u22652 GU and GI toxicities, respectively, and 42 (6.8%) and 27 (4.4%) patients had late Grade \u22652 GU and GI toxicities, respectively. Diabetes and transurethral resection independently predicted late Grade 2 GU toxicity, but no significant predictor of late Grade \u22652 GI toxicity was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Localized PC was effectively and safely treated with definitive RT using the SIB technique to deliver 86\u2009Gy to the IPL in 39 fractions without severe late toxicity. This finding must be validated with long\u2010term results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24558","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T03:29:51Z","timestamp":1683948591000},"page":"1158-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment outcomes of simultaneous integrated boost to intraprostatic lesions with external beam radiotherapy in localized prostate cancer patients"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-9021","authenticated-orcid":false,"given":"Cem","family":"Onal","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Adana Dr Turgut Noyan Research and Treatment Center Baskent University Faculty of Medicine  Adana Turkey"},{"name":"Department of Radiation Oncology Baskent University Faculty of Medicine  Ankara 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