{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:52:06Z","timestamp":1789998726439,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of urinary continence and erectile function on the quality of life in men undergoing radical prostatectomy (RP) for prostate cancer (PC), we analyzed the preoperative and 1\u2010year postoperative outcomes of five functional domains and their influencing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In this prospective study, all patients undergoing open or robot\u2010assisted RP between Febuary 2017 and March 2020 in a single academic center were included. Patient\u2010reported outcomes were assessed pre\u2010 and 12 months postoperatively using the Expanded Prostate Index Composite (EPIC\u201026) survey, evaluating continence, irritative\/obstructive micturition, gastrointestinal symptoms, sexuality, and overall vitality. We examined the impact of RP on sexual function and urinary continence using multivariable logistic regression models, accounting for patient and tumor characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1313 consecutive patients gave consent for study participation and completed both surveys. The median age was 66 years (IQR: 60\u221270). The majority of patients (<jats:italic>n<\/jats:italic>\u2009=\u2009601, 46%) had an intermediate risk PC. Robotic RP was performed in 71.6% and nerve\u2010sparing technique in 81% of the cases. The median pre\u2010 versus postoperative scores were the following: urinary continence 100 (IQR:\u00a091.8\u2212100) versus 85.5 (64.8\u2212100), irritative micturition 87.5 (IQR: 75\u2212100) versus 93.8 (IQR: 87.5\u2212100), gastrointestinal symptoms the same with 100 (IQR: 95.8\u2212100), vitality 95 (IQR: 80\u2212100) versus 90 (IQR: 75\u2212100), and erectile function 65.3 (IQR: 38.8\u221287.5) versus 22.2 (IQR: 12.5\u221248.7), respectively. Age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), risk classification (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and nerve\u2010sparing surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.016) were associated with good sexual function (EPIC\u201026 score \u226560), while only age (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) was statistically significantly associated with good urinary continence (EPIC\u201026 score \u226580).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010modifiable factors such as age and PC risk classification impact urinary continence and sexual function after RP. Nevertheless, urologic surgeons should further focus on improving nerve\u2010sparing techniques, the only modifiable variable, to reduce the surgery's negative impact on urinary continence and sexual function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24591","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:34:26Z","timestamp":1687653266000},"page":"1290-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional outcome after radical prostatectomy in 1313 patients: A single\u2010center study"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-2238","authenticated-orcid":false,"given":"Lorine","family":"Haeuser","sequence":"first","affiliation":[{"name":"Department of Urology and Neuro\u2010Urology, Marien Hospital Herne Ruhr\u2010University Bochum Herne 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