{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:05:15Z","timestamp":1774577115049,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salvage cryotherapy (SCT) is widely used to treat prostate cancer (PCa) recurrence after radiotherapy (RT). We studied the intermediate oncological and functional outcomes of patients who underwent SCT following cryotherapy (CRYO\u2010SCT) recurrence and compare it to recurrence after brachytherapy (BT\u2010SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An IRB\u2010approved retrospective cohort study utilizing patient data from the Cryo On\u2010Line Data\u00a0Registry and the Duke PCa database between 1992 and 2016. Biochemical recurrence (BCR) using Phoenix criteria was the primary endpoint assessed at 2\u2010 and 5\u2010years post\u2010SCT. Secondary endpoints assessed functional outcomes including urinary continence, erectile function, and recto\u2010urethral fistula. Association between treatment and biochemical progression\u2010free survival was assessed using inverse probability weighted (IPTW) Cox proportional hazards regression. The differences in the secondary functional outcomes were assessed by Pearson's <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test or Fisher's exact test, corrected for IPTW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 194 patients met inclusion criteria. The BCR rate for BT\u2010SCT and CRYO\u2010SCT was 23 (20.4%) and 17 (21%) at 2 years and 30 (26.5%) and 22 (27.2%) at 5 years according to Phoenix criteria. There was no statistical difference in 2 years\u00a0(hazard ratio [HR] 0.9; 95% confidence interval [CI], 0.5\u20131.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.7) or 5\u2010year BCR (HR: 0.86; 95% CI, 0.5\u20101.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.6) between the groups. The functional outcomes like urinary continence (<jats:italic>p<\/jats:italic>\u2009=\u20090.4), erectile function (<jats:italic>p<\/jats:italic>\u2009=\u20090.1), and recto\u2010urethral fistula (<jats:italic>p<\/jats:italic>\u2009=\u20090.3) were not statistically different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRYO\u2010SCT appears to be well tolerated, with comparable oncological and functional outcomes to patients failing primary BT. The findings also demonstrated that SCT can render a significant number of patients biochemically free of disease after initial CRYO with minimal morbidity. SCT is a viable treatment option to salvage local PCa recurrence following either BT or cryoablation failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24600","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T05:03:54Z","timestamp":1689829434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intermediate\u2010term oncological and functional outcomes of salvage cryotherapy for the management of prostate cancer recurrence after primary brachytherapy versus primary cryotherapy: A propensity\u00a0score\u2010matched analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-9558","authenticated-orcid":false,"given":"Sriram","family":"Deivasigamani","sequence":"first","affiliation":[{"name":"Department of Urologic Surgery and Duke Prostate Center Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-3168","authenticated-orcid":false,"given":"Hazem","family":"Orabi","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery and Duke Prostate Center Duke University Medical Center Durham North Carolina USA"},{"name":"Urology Department Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7468","authenticated-orcid":false,"given":"Ahmed","family":"El\u2010Shafei","sequence":"additional","affiliation":[{"name":"Department of Urology University of Florida Health Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-1973","authenticated-orcid":false,"given":"Eric S.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery and Duke Prostate Center Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-9102","authenticated-orcid":false,"given":"Srinath","family":"Kotamarti","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery and Duke Prostate Center Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Aminsharifi","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery and Duke Prostate Center Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Urology Penn State Health Milton S. 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