{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T14:24:19Z","timestamp":1750515859466,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whole exome sequencing (WES) furthered our understanding of various tumors. We assessed the occurrence of germline likely pathogenic\/pathogenic (LP\/P) variants, disease features, and clinical outcomes in early\u2010onset prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study (<jats:italic>N<\/jats:italic>\u2009=\u2009134) included consecutive prostate cancer patients who donated blood samples for research purposes to the Kahn\u2010Sagol\u2010Maccabi biobank. Patients diagnosed at &gt;65 years were excluded. Clinical characteristics were extracted from the medical records. Germline WES was performed with analysis reporting on oncogenetic, two immunogenic, and a secondary minimum list panels (121, 468, 76, and 59 genes, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at diagnosis was 61 (range 46\u201365) years; 131 (98%) were diagnosed with local disease. The median follow\u2010up time from diagnosis was 14 (range &lt;1\u201325) years. Of the patients with local disease, 32 (24%) and 10 (8%) had biochemical and distant recurrences, respectively. Twenty\u2010five patients (19%) had \u22651 additional cancer (excluding non\u2010melanoma skin cancer), most frequently bladder (6), colorectal (5), and lymphoma (5). Seven (5%) deaths were reported, with only one related to prostate cancer. LP\/P variants were identified in 8 patients (6%), all in genes from the oncogenetic panel: <jats:italic>ATM<\/jats:italic>, <jats:italic>BRCA1<\/jats:italic> (in two patients), <jats:italic>BRCA2<\/jats:italic> (in two patients), <jats:italic>HOXB13<\/jats:italic>, <jats:italic>MUTYH<\/jats:italic>, and <jats:italic>MYH7<\/jats:italic>. Of these eight patients, with a median follow\u2010up of 7 years (range &lt;1\u201315), two (25%) had biochemical recurrences, one had (12.5%) distant recurrence, and no deaths were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort of 134 early\u2010onset prostate cancer patients, we identified germline LP\/P variants in an oncogenetic panel in 6% of participants, with no unique clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24622","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:15:04Z","timestamp":1697451304000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Whole exome germline sequencing in early\u2010onset prostate cancer patients: Genomic findings and clinical outcomes"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-540X","authenticated-orcid":false,"given":"Nava","family":"Siegelmann\u2010Danieli","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Professional Medicine Maccabi Healthcare Services Tel Aviv Israel"},{"name":"KSM Research and Innovation Center Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Neiman","sequence":"additional","affiliation":[{"name":"Davidoff Cancer Center Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avital","family":"Bareket\u2010Samish","sequence":"additional","affiliation":[{"name":"BioInsight Ltd. Binyamina Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Racheli","family":"Berger","sequence":"additional","affiliation":[{"name":"Genetic Institute, Maccabi Healthcare Services Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Peretz","sequence":"additional","affiliation":[{"name":"KSM Research and Innovation Center Maccabi Healthcare Services Tel Aviv Israel"},{"name":"Tipa Biobank, KSM Research and Innovation Center, Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillel","family":"Alapi","sequence":"additional","affiliation":[{"name":"KSM Research and Innovation Center Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erez","family":"Tsur","sequence":"additional","affiliation":[{"name":"Genetic Institute, Maccabi Healthcare Services Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Patalon","sequence":"additional","affiliation":[{"name":"KSM Research and Innovation Center Maccabi Healthcare Services Tel Aviv Israel"},{"name":"Tipa Biobank, KSM Research and Innovation Center, Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella","family":"Beller","sequence":"additional","affiliation":[{"name":"Tipa Biobank, KSM Research and Innovation Center, Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Rimler","sequence":"additional","affiliation":[{"name":"Tipa Biobank, KSM Research and Innovation Center, Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"KSM Research and Innovation Center Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai","family":"Shohat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Genetic Institute, Maccabi Healthcare Services Rehovot Israel"},{"name":"The Genomics Unit, Sheba Cancer Research Center Sheba Medical Center Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.09.006"},{"key":"e_1_2_10_3_1","unstructured":"National Cancer Institute \u2010 Surveillance Epidemiology and End Results (SEER) Program. 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Version 3. 2022.https:\/\/www.nccn.org\/guidelines\/category_1"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:40:57Z","timestamp":1704292857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/pros.24622"],"URL":"https:\/\/doi.org\/10.1002\/pros.24622","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"type":"print","value":"0270-4137"},{"type":"electronic","value":"1097-0045"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"2023-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}