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Genetic registries address these gaps by identifying candidates for recently approved targeted treatments, expanding clinical trial data examining specific gene mutations, and understanding effects of targeted treatments in the real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PROMISE Registry is a 20\u2010year (5\u2010year recruitment, 15\u2010year follow\u2010up), US\u2010wide, prospective genetic registry for prostate cancer patients. Five thousand patients will be screened through an online at\u2010home germline testing to identify and enroll 500 patients with germline mutations, including: pathogenic or likely pathogenic variants and variants of uncertain significance in genes of interest. Patients will be followed for 15 years and clinical data with real time patient reported outcomes will be collected. Eligible patients will enter long\u2010term follow\u2010up (6\u2010month PRO surveys and medical record retrieval). As a virtual study with patient self\u2010enrollment, the PROMISE Registry may fill gaps in genetics services in underserved areas and for patients within sufficient insurance coverage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PROMISE Registry opened in May 2021. 2114 patients have enrolled to date across 48 US states and 23 recruiting sites. 202\u00a0patients have met criteria for long\u2010term follow\u2010up. PROMISE is on target with the study's goal of 5000 patients screened and 500 patients eligible for long\u2010term follow\u2010up by 2026.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PROMISE Registry is a novel, prospective, germline registry that will collect long\u2010term patient outcomes data to address current gaps in understanding resulting from recently FDA\u2010approved treatments and updates to genetic testing recommendations for prostate cancer. Through inclusion of a broad nationwide sample, including underserved patients and those unaffiliated with major academic centers, the PROMISE Registry aims to provide access to germline genetic testing and to collect data to understand disease characteristics and treatment responses across the disease spectrum for prostate cancer with rare germline genetic variants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24650","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T20:22:44Z","timestamp":1700079764000},"page":"292-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PROMISE Registry: A prostate cancer registry of outcomes and germline mutations for improved survival and treatment effectiveness"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-1858","authenticated-orcid":false,"given":"Channing J.","family":"Paller","sequence":"first","affiliation":[{"name":"Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-2951","authenticated-orcid":false,"given":"Pedro C.","family":"Barata","sequence":"additional","affiliation":[{"name":"University Hospitals Seidman Cancer Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lorentz","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J.","family":"Appleman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Hillman Cancer Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Center for Prostate &amp; Urologic Cancers Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffani A.","family":"DeMarco","sequence":"additional","affiliation":[{"name":"Inova Translational Medicine Institute Fairfax Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dreicer","sequence":"additional","affiliation":[{"name":"University of Virginia Comprehensive Cancer Center Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Ann B.","family":"Elrod","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center, Clinical Research Division Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fleming","sequence":"additional","affiliation":[{"name":"Virginia Oncology Associates Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"George","sequence":"additional","affiliation":[{"name":"Robert H. 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