{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:16:55Z","timestamp":1790223415017,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the variation of multiparametric magnetic resonance imaging (mpMRI) positive predictive value (PPV)\u00a0according to each patient's risk of clinically significant prostate cancer (csPCa)\u00a0based exclusively on clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 999 patients with positive mpMRI (PI\u2010RADS\u2009\u2265\u20093) receiving targeted (TBx)\u00a0plus systematic prostate biopsy. We built a multivariable logistic regression analysis (MVA)\u00a0using clinical risk factors to calculate the individual patients' risk of harboring csPCa at TBx. A second MVA tested the association between individual patients' clinical risk and mpMRI PPV accounting for the PI\u2010RADS score. Finally, we plotted the PPV of each PI\u2010RADS\u00a0score by the individual patient pretest probability of csPCa using a LOWESS approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, TBx found csPCa in 21%, 51%, and 80% of patients with PI\u2010RADS\u00a03, 4, and 5 lesions, respectively. At MVA, age, PSA, digital rectal examination (DRE),\u00a0and prostate volume were significantly associated with the risk of csPCa at biopsy. DRE yielded the highest odds ratio (OR:\u00a02.88; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The individual patient's clinical risk was significantly associated with mpMRI PPV (OR: 2.49; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) using MVA. Plotting the mpMRI PPV according to the predicted clinical risks, we observed that for patients with clinical risk close to 0 versus patients with risk higher than 90%, the mpMRI PPV of PI\u2010RADS\u00a03, 4, and 5 ranged from 0% to 75%, from 0% to 96%, and from 45% to 100%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>mpMRI PPV varies according to the individual pretest patient's risk based on clinical factors. These findings should be considered in the decision\u2010making process for patients with suspect MRI findings referred for a prostate biopsy. Moreover, our data support the need for further studies to create an individualized risk prediction tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24665","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T12:59:17Z","timestamp":1703681957000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Variability of mpMRI diagnostic performance according to the upfront individual patient risk of having clinically significant prostate cancer"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-6876","authenticated-orcid":false,"given":"Francesco","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Soldera Prostate Cancer Lab, URI IRCCS San Raffaele Scientific Institute Vita\u2010Salute San Raffaele University Milan 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