{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:20:58Z","timestamp":1790806858600,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the biochemical failure (FFBF) and prostate cancer specific survival (PCSS) rates of patients with intermediate\u2010risk prostate cancer (IR\u2010PC) who were treated with 6 months of androgen deprivation therapy (ADT) with 78\u2009Gy to the prostate, those treated with ADT and focal boost (FB) of 86\u2009Gy to intraprostatic lesion (IPL) using the simultaneous\u2010integrated boost (SIB) technique, and those treated with SIB alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective analysis of 320 IR\u2010PC patients treated between January 2012 and April 2021 was performed. Patients were divided into three groups based on their treatment arm: 78\u2009+\u2009ADT (109 patients, 34.1%), 78\/86 (102 patients, 31.8%), and 78\/86\u2009+\u2009ADT. Univariable and multivariable analyses were used to determine prognostic factors for FFBF and PCSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 8.8 years. The 8\u2010year FFBF and PCSS rates were 88.6% and 99.0%. Patients who received ADT had significantly higher pretreatment PSA levels and clinical tumor stage. Disease progression occurred in 45 patients (7.3%) at a median of 41.9 months after definitive radiotherapy (RT). Younger age, positive core biopsy (PCB)\u2009\u2265\u200950%, and the absence of ADT were all independent predictors of poor FFBF in multivariate analysis, whereas patients with PCB\u2009&lt;\u200950% who were also given ADT had better PCSS. Patients treated with 78\/86\u2009Gy alone had worse FFBF than those treated with 78\u2009Gy and ADT (Hazard ratio [HR]\u2009=\u20093.39 [95% CI\u2009=\u20091.46\u20137.88]; <jats:italic>p<\/jats:italic>\u2009=\u20090.005), as well as than those treated with 78\/86\u2009Gy and ADT (HR\u2009=\u20093.21 [95% CI\u2009=\u20091.23\u20136.46]; <jats:italic>p<\/jats:italic>\u2009=\u20090.009). However, FB to IPL has no effect on PCSS in multivariable analysis. There was no significant difference between treatment groups in terms of acute and late Grade \u22652 genitourinary or gastrointestinal toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrated that patients who received 78\/86 alone did worse than patients who received ADT with either 78 or 78\/86\u2009Gy. However, because IR\u2010PC patients are so diverse, additional prospective trials are needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24693","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T04:06:17Z","timestamp":1711425977000},"page":"763-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of dose\u2010escalation radiotherapy with simultaneous\u2010integrated\u2010boost on the use of short\u2010term androgen deprivation therapy in patients with intermediate risk prostate cancer"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-9021","authenticated-orcid":false,"given":"Cem","family":"Onal","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Baskent University Faculty of Medicine Adana Dr Turgut Noyan Research and Treatment Center Adana Turkey"},{"name":"Department of Radiation Oncology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan Cem","family":"Guler","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Baskent University Faculty of Medicine Adana Dr Turgut Noyan Research and Treatment Center Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurcan","family":"Erbay","sequence":"additional","affiliation":[{"name":"Department of Radiology Baskent University Faculty of Medicine Adana Dr Turgut Noyan Research and Treatment Center Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-3391","authenticated-orcid":false,"given":"Aysenur","family":"Elmali","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Baskent University Faculty of Medicine Ankara 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need for androgen deprivation therapy in patients with intermediate\u2010risk prostate cancer treated with dose\u2010escalated external beam radiation therapy","volume":"24","author":"Dong Y","year":"2017","journal-title":"Can J 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