{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:26:14Z","timestamp":1767986774135,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate\u2010specific membrane antigen (PSMA) Positron emission tomography\/computed tomography (PET\/CT) has become a crucial imaging modality for the staging of patients with prostate cancer. The purpose of this study is to retrospectively determine the frequency, anatomical distribution, and clinical\u2010pathologic correlates of extra\u2010nodal and extra\u2010osseous metastatic prostate cancer detected on PSMA PET\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All available 650 PSMA PET\/CT performed in patients with biopsy\u2010proved prostate cancer in our institution between September 2021 and December 2023 were reviewed for the presence of extra\u2010nodal and extra\u2010osseous metastatic disease (M1C disease). Thirty\u2010four patients with M1C disease were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most frequent sites of visceral\/soft tissue metastases were the lungs (58.8%), liver (23.5%) and adrenal glands (20.6%). 75% of patients with lung metastases detected on PSMA PET\/CT had concurrent intrathoracic lymph node involvement. A higher frequency of patients with M1C disease (55.9%) had a high Gleason score. The median prostate\u2010specific antigen (PSA) level at the time of the PSMA scan was 20.16\u2009ng\/mL. There was a statistically significant association between PSA level and osseous disease (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), as well as PSA level and nodal disease (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). While a large number of patients had concurrent osseous and nodal disease (82.4% and 79.4%, respectively), no visceral\/soft tissue sites demonstrated a significant association with the presence of osseous or nodal involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the increasing utilization of PSMA PET\/CT, increased knowledge of the location and pattern of distribution of visceral\/soft tissue metastatic sites is crucial not only for staging but also to better understand patterns of therapeutic response. We identified the lungs, liver and adrenal glands as the most common visceral\/soft tissue metastatic sites from prostate cancer. We found that higher PSA levels at the time of PSMA PET\/CT imaging were positively associated with concurrent osseous and nodal involvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24795","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T05:14:21Z","timestamp":1726722861000},"page":"13-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A single\u2010center retrospective review of metastatic prostate cancer on PSMA position emission tomography\/computed tomography: Beyond lymph nodes and bones"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-8778","authenticated-orcid":false,"given":"Gabriela N. C.","family":"De Jesus","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Yale New Haven Hospital New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Radiology Section of Nuclear Medicine, Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanta","family":"Karak","sequence":"additional","affiliation":[{"name":"Department of Radiology Section of Nuclear Medicine, Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Shearier","sequence":"additional","affiliation":[{"name":"Department of Radiology Clinical Research Center, Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1191"},{"key":"e_1_2_8_3_1","volume-title":"SEER cancer stat facts: Prostate cancer","author":"National Cancer Institute","year":"2024"},{"key":"e_1_2_8_4_1","volume-title":"Prostate cancer stages","author":"American Cancer Society","year":"2024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22742"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7533"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080713"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-020-00618-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184470"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112594"},{"key":"e_1_2_8_11_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Prostate Cancer V.1.2023","author":"National Comprehensive Cancer Network"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.02.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.198119"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.7270"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-020-01529-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001959"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.862.10673942"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T11:45:43Z","timestamp":1733139943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/pros.24795"],"URL":"https:\/\/doi.org\/10.1002\/pros.24795","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"2024-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}