{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:25:21Z","timestamp":1793139921348,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to assess the safety and effectiveness of TRUS guided betamethasone injections in refractory cases of chronic nonbacterial prostatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Forty\u2010five patients with refractory CNP were included in a prospective cohort clinical trial. Six injections of betamethasone sodium sulfate were guided by TRUS. After injection: assessment of NIH\u2010CPSI, IPSS, IIEF, GRA and VAS were performed 1, 4, and 12 weeks after injection. Prostatitis symptoms were measured by NIH\u2010CPSI. We considered the minimal clinically important difference (MCID) as a 25% decrease or a six\u2010point reduction from baseline. We considered the MCID of the IIEF to be at least an increase of 4 points. We considered the MCID of the IPSS score to be three points and the MCID for the VAS score to be a 25%\u201335% change of the initial score. Regarding the global response assessment (GRA), scores 5\u20137 means significant success rate of perceived treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to total NIH CPSI score, the success rate of injected cases was 71% after 1 week, dropping to 55.6% after 4 weeks and 44.4% after 12 weeks. According to IPSS questionnaire, the MD (mean difference) is \u22124.09\u2009\u00b1\u20093.5, \u22123.8\u2009\u00b1\u20093.83 and \u22123.47\u2009\u00b1\u20093.92. According to the IIEF questionnaire, the success rate was 22% and 26.7% after 4 and 12 weeks respectively. According to GRA, successful pain control was reported in 82%, 71% and 64.4% after 1, 4 and 12 weeks, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraprostatic betamethasone injection is a simple, safe, and feasible procedure in refractory cases with CNP with predominant pain and urinary symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24819","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T10:08:35Z","timestamp":1731838115000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Efficacy of Intra\u2010Prostatic Injection of Betamethasone for Refractory Chronic Nonbacterial Prostatitis: A Prospective Cohort Clinical Study"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-2996","authenticated-orcid":false,"given":"Ahmed Yehia","family":"Abdelaziz","sequence":"first","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ali","family":"Kishk","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Meshref","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Elfayomy","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Rammah","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Hossam","family":"Abozamel","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.04.035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14988"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2017.12.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S170400"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181f89971"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"87","article-title":"Echoguided Drug Infiltration in Chronic Prostatitis: Results of a Multi\u2010Centre Study","volume":"77","author":"Guercini F.","year":"2005","journal-title":"Archivio Italiano di Urologia Andrologia"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.3.236"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2009.22"},{"issue":"3","key":"e_1_2_10_10_1","article-title":"Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper\u2010Based Visual Analog Scale in Adults","volume":"2","author":"Delgado D. 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