{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:35Z","timestamp":1791312095798,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The use of multiparametric magnetic resonance imaging (MRI) to guide prostate biopsies has improved cancer detection rates, particularly for high\u2010grade tumors. However, despite guidelines recommending biopsies for lesions with a Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score \u2265\u20093, the clinical significance of PI\u2010RADS 3 lesions remains uncertain. This uncertainty, coupled with the cost and potential complications of biopsies, underscores the need for more accurate risk stratification strategies to avoid unnecessary procedures. Prostate\u2010specific antigen density (PSAD) and index lesion volume are emerging as potential contributors to improve risk assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective analysis of patients who had undergone an MRI\u2010guided transrectal ultrasound (TRUS) prostate biopsy at a tertiary care institution. Patients with PI\u2010RADS 3 lesions were included, and data on demographics, prostate\u2010specific antigens (PSA), PSAD, lesion diameter, and pathology results were collected. The relationships between PSAD, lesion volume, and pathology outcomes were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 213 patients included, 40 were diagnosed with prostate cancer. PSAD and PSAD x lesion diameter were significantly higher in the patients diagnosed with prostate cancer than those with benign lesions. Among the prostate cancer patients, clinically significant prostate cancer (csPCa) had a higher mean PSAD value than clinically insignificant prostate cancer (cisPCa). ROC analysis found PSAD x lesion diameter to have the highest discriminatory power for detecting csPCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>MRI\u2010guided biopsies offer targeted sampling but the clinical significance of PI\u2010RADS 3 lesions remains uncertain. Index lesion volume and PSAD are promising adjunctive markers for risk assessment. Combining these factors could facilitate the avoidance of unnecessary biopsies and improve the detection of csPCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Incorporating PSAD and index lesion volume into biopsy decision\u2010making may enhance risk stratification, particularly for PI\u2010RADS 3 lesions. Further research is needed to validate these findings and enhance the risk assessment strategies used in making decisions regarding prostate biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24840","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T11:38:33Z","timestamp":1734262713000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["PSA Density and Lesion Volume: Key Factors in Avoiding Unnecessary Biopsies for PI\u2010RADS 3 Lesions"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3747-0869","authenticated-orcid":false,"given":"Ali","family":"Ayranci","sequence":"first","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-9396","authenticated-orcid":false,"given":"Ufuk","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-7861","authenticated-orcid":false,"given":"Huseyin Burak","family":"Yazili","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-7664","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Erdal","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-8288","authenticated-orcid":false,"given":"Akif","family":"Erbin","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Sarilar","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Ozgor","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17942"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.11.031"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1807507"},{"key":"e_1_2_13_6_1","unstructured":"European Association of Urology. 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EAU; (2023): 33\u201334.https:\/\/uroweb.org\/guidelines\/prostate-cancer."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15277"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021204112"},{"key":"e_1_2_13_9_1","article-title":"Prebiopsy IMPROD Biparametric Magnetic Resonance Imaging Combined With Prostate\u2010Specific Antigen Density in the Diagnosis of Prostate Cancer: An External Validation Study","volume":"6","author":"Knaapila J.","year":"2019","journal-title":"European Urology Oncology"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2017.01058"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.038"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2795-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017152877"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25372"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3 <933::AID-CNCR2820711408>3.0.CO;2-L"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2020.20238"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24078"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.06.014"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.05.004"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:38:15Z","timestamp":1738157895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/pros.24840"],"URL":"https:\/\/doi.org\/10.1002\/pros.24840","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"assertion":[{"value":"2024-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}