{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:19:50Z","timestamp":1777889990314,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of abiraterone acetate varies among patients with high\u2010risk metastatic castration\u2010sensitive prostate cancer (mCSPC). Both androgen receptor (AR) and cytokeratin 18 (CK18) are markers of the luminal lineage of prostate cancer, and their expression levels have been suggested to affect the response to androgen deprivation therapy (ADT). This study aimed to predict the efficacy of abiraterone acetate in high\u2010risk mCSPC via immunohistochemical staining of biopsy specimens obtained at the time of prostate cancer diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 44 patients treated with abiraterone acetate in combination with ADT. AR and CK18 expression in prostate biopsy specimens were assessed using immunohistochemical staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AR and CK18 staining was not significantly associated with overall survival (OS). However, low AR staining was significantly associated with a shorter time to castration\u2010resistant prostate cancer (TTCRPC) compared with high AR staining (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). Similarly, low CK18 staining was significantly associated with a shorter TTCRPC compared with high CK18 staining (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunohistochemical analysis of AR or CK18 expression in biopsy specimens may serve as a predictive biomarker of high\u2010risk mCSPC treated with abiraterone acetate.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> None<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24865","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T12:39:17Z","timestamp":1738327157000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical Analysis of Androgen Receptor Expression Predicts the Prognosis of Metastatic Castration\u2010Sensitive Prostate Cancer Patients Receiving Abiraterone Acetate"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-0507","authenticated-orcid":false,"given":"Mitsuhisa","family":"Nishimoto","sequence":"first","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-6572","authenticated-orcid":false,"given":"Marco A.","family":"De Velasco","sequence":"additional","affiliation":[{"name":"Department of Genome Biology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-6295","authenticated-orcid":false,"given":"Yutaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Nara Hospital Ikoma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-6287","authenticated-orcid":false,"given":"Saizo","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4276-1735","authenticated-orcid":false,"given":"Yasunori","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Nara Hospital Ikoma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2572-5071","authenticated-orcid":false,"given":"Shingo","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-942X","authenticated-orcid":false,"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-2240","authenticated-orcid":false,"given":"Shogo","family":"Adomi","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-4804","authenticated-orcid":false,"given":"Eri","family":"Banno","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-366X","authenticated-orcid":false,"given":"Yoshitaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-3760","authenticated-orcid":false,"given":"Takafumi","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-5925","authenticated-orcid":false,"given":"Akihide","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Nara Hospital Ikoma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-0391","authenticated-orcid":false,"given":"Kazuhiro","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-9523","authenticated-orcid":false,"given":"Hirotsugu","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-7497","authenticated-orcid":false,"given":"Kazutoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.10.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704174"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03488"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00799"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08361"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0751"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880101)61:1<195::aid-cncr2820610133>3.0.co;2-y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.769068"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04200-2"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4521"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24019"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.06.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-009"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:03:29Z","timestamp":1744783409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/pros.24865"],"URL":"https:\/\/doi.org\/10.1002\/pros.24865","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}