{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:33:02Z","timestamp":1791613982419,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The Prognostic Nutritional Index (PNI), reflects the nutritional and immunological status of the patient and has been associated with outcomes in various cancers. In this study, the prognostic significance of PNI in metastatic hormone\u2010sensitive prostate cancer (mHSPC) and its potential role in guiding treatment decisions between abiraterone acetate and enzalutamide is investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis was performed on 167 mHSPC patients treated between 2019 and 2024. PNI was calculated using the formula: 10\u2009\u00d7\u2009serum albumin (g\/dL)\u2009+\u20090.005\u2009\u00d7\u2009total lymphocyte count (\/mm\u00b3). Patients were stratified into high and low PNI groups according to a cutoff value of 49.98, determined via receiver operating characteristic (ROC) analysis. Survival outcomes, including overall survival (OS), radiographic progression\u2010free survival (rPFS), and PSA progression\u2010free survival (PSA\u2010PFS), were assessed. Treatment responses to abiraterone acetate and enzalutamide were compared within PNI strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with PNI\u2009&gt;\u200949.98 had significantly longer median OS than those with PNI\u2009\u2264\u200949.98 (36.6 months vs. 30.0 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Multivariate analysis identified high PNI, ECOG performance status 0\u20131, and absence of visceral metastasis as independent predictors of improved OS. Among patients with low PNI, those treated with enzalutamide had superior OS compared to those receiving abiraterone acetate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), while no significant OS difference was noted between treatments in the high PNI group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PNI serves as a significant prognostic biomarker in mHSPC, correlating with overall survival and potentially influencing treatment efficacy between abiraterone acetate and enzalutamide. Integrating PNI into clinical practice may aid in tailoring individualized treatment options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.24876","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:30:31Z","timestamp":1740011431000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Nutritional Index as a Biomarker in Metastatic Hormone\u2010Sensitive Prostate Cancer: Impact on Survival and Treatment Optimization"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-3239","authenticated-orcid":false,"given":"Muhammet Bekir","family":"Hacioglu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Trakya University Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-2360","authenticated-orcid":false,"given":"Ahmet","family":"Kucukarda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tekirda\u011f \u0130smail Fehmi Cumal\u0131oglu City Hospital Tekirda\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-5396","authenticated-orcid":false,"given":"Ivo","family":"Gokmen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology \u00c7anakkale Mehmet Akif Ersoy City Hospital \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1455-471X","authenticated-orcid":false,"given":"Ali Fuat","family":"Gurbuz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Necmettin Erbakan University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-9501","authenticated-orcid":false,"given":"Murat","family":"Araz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Necmettin Erbakan University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-0970","authenticated-orcid":false,"given":"Fatma Akdag","family":"Kahvecioglu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-7405","authenticated-orcid":false,"given":"Ilhan","family":"Hacibekiroglu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-1191","authenticated-orcid":false,"given":"Orhun","family":"Akdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-3569","authenticated-orcid":false,"given":"Ozan","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-3845","authenticated-orcid":false,"given":"Fatma Aysun","family":"Akkus","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Trakya University Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-1018","authenticated-orcid":false,"given":"Abdussamet","family":"\u00c7elebi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-5603","authenticated-orcid":false,"given":"Osman","family":"Kostek","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2158-3490","authenticated-orcid":false,"given":"Bulent","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medicine Faculty Trakya University Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2022.03.07"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S303215"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00367-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119115"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.046"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-018-0588-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175434"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.12.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117232"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262630"},{"issue":"9","key":"e_1_2_12_14_1","first-page":"1001","article-title":"[Prognostic 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Espa\u00f1olas"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00689-9"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00063-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30082-8"},{"issue":"12","key":"e_1_2_12_21_1","article-title":"Abiraterone Acetate in Combination With Androgen Deprivation Therapy Compared to Androgen Deprivation Therapy Only for Metastatic Hormone\u2010Sensitive Prostate Cancer","volume":"12","author":"Sathianathen N. 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