{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:01:44Z","timestamp":1783706504931,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:sup>177<\/jats:sup>Lu\u2010vipivotide tetraxetan (<jats:sup>177<\/jats:sup>Lu\u2010PSMA\u2010617, LuPSMA) improves overall survival in patients with metastatic castration\u2010resistant prostate cancer (mCRPC) after at least one taxane chemotherapy and androgen receptor pathway inhibitor. There are limited data on the clinical course and outcomes of patients with mCRPC after receipt of LuPSMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried an IRB\u2010approved prospectively maintained registry of all patients with mCRPC who received standard\u2010of\u2010care LuPSMA at our institution between June 2022 and January 2024. Clinical data about LuPSMA and subsequent therapies were extracted from the electronic medical record, including the type and number of subsequent systemic therapies, reason for treatment cessation, hematologic toxicity and supportive treatment, and PSA50 response to subsequent therapy (defined as a\u2009\u2265\u200950% decrease in PSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 146 patients were evaluated; mean age 72 (range 52\u201387), observed median follow\u2010up 5.9 months (range 0.51\u201318.7). Forty\u2010four received systemic treatment after LuPSMA. The most common subsequent treatment after LuPSMA was chemotherapy (<jats:italic>n<\/jats:italic>\u2009=\u200927), primarily cabazitaxel\u2009\u00b1\u2009carboplatin\/cisplatin (<jats:italic>n<\/jats:italic>\u2009=\u200923), and the median number of cycles received was 4 (range 1\u20137). In 35\/44 men with available hematologic toxicity data, 13 developed grade\u2009\u2265\u20093 anemia, 7 had\u2009\u2265\u2009grade 3 thrombocytopenia, and 16 received hematologic support. PSA50 to post\u2010LuPSMA treatment occurred in 10\/36 (28%) evaluable patients. Median overall survival from subsequent systemic therapy was 7.6 months (95% CI 5.81\u2013NR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>30% of patients receiving standard\u2010of\u2010care LuPSMA received subsequent therapy, mostly cabazitaxel\u2010containing regimens. Post\u2010LuPSMA treatment appeared tolerable and was associated with a PSA50 response rate of 28%. These outcomes may be biased by limited standard\u2010of\u2010care life\u2010prolonging treatment options at the time of LuPSMA FDA approval, but it also highlights the continued need to develop novel therapeutic strategies for mCRPC post\u2010LuPSMA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24880","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:23:56Z","timestamp":1742361836000},"page":"742-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of Subsequent Therapies After <sup>177<\/sup>Lu\u2010Vipivotide Tetraxetan for Metastatic Castrate\u2010Resistant Prostate Cancer: A Tertiary Cancer Center Experience"],"prefix":"10.1002","volume":"85","author":[{"given":"Meryam","family":"Losee","sequence":"first","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kavanaugh","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"},{"name":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Data Science Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Haberman","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolivette","family":"Ritzer","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wolanski","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Bhimaniya","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9344-6631","authenticated-orcid":false,"given":"Atish D.","family":"Choudhury","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Stoltenberg","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry L.","family":"Kilbridge","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Morgans","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pomerantz","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sakellis","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Ellen","family":"Taplin","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao X.","family":"Wei","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Data Science Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Center for Systems Biology, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-4702","authenticated-orcid":false,"given":"Praful","family":"Ravi","sequence":"additional","affiliation":[{"name":"The Lank Center for Genitourinary Oncology, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-078X","authenticated-orcid":false,"given":"Heather","family":"Jacene","sequence":"additional","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Radiology Brigham &amp; 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