{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:37:41Z","timestamp":1793860661771,"version":"4.6.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>PSMA PET\/CT has previously shown superior performance in nodal staging of prostate cancer (PCa) and may be used to reduce the number of unnecessary PLND procedures. This study aims to assess the performance of PSMA PET\/CT in nodal staging of intermediate\u2010risk prostate cancer and to evaluate the effect of PLND on oncological outcomes of intermediate\u2010risk prostate cancer patients with a negative PSMA PET\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 308 patients with intermediate\u2010risk PCa who underwent PSMA PET\/CT for nodal staging between January 2014 and July 2024 were included in the study. Patients who underwent PLND had higher PSA and higher rates of PIRADS\u20105 and biopsy grade\u2010group 3 disease. A 1:1 propensity score matching was performed to eliminate patient characteristics differences between groups and 140 patients were included in the final analysis. PSA persistence rates (\u2009\u2265\u20090.1\u2009ng\/dL) and biochemical recurrence (BCR;\u2009\u2265\u20090.2\u2009ng\/dL) rates after RP were recorded. Kaplan\u2010Meier curves were constructed to evaluate oncological outcomes. Log\u2010rank test was utilized to compare oncological outcomes in patients with and without PLND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PSMA PET\/CT on nodal staging were 53.3%, 95%, 47.1%, and 96.1%, respectively. The NPV of PSMA PET\/CT in patients with biopsy GG3 disease (96.3%) was similar to those with biopsy GG2 disease (95.6%). The median follow\u2010up after propensity score matching was 20.7 months. The 24\u2010month BCR\u2010free survival rates were 83.7% and 86.9% in the PLND\u2010RP group and RP\u2010only groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.078).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NPV of PSMA PET\/CT in determining LNI was remarkable in patients with intermediate\u2010risk PCa and PLND was found to have no impact on oncological outcomes. Therefore PLND may be omitted to decrease surgery\u2010related complications in patients with intermediate\u2010risk PCa a negative PSMA PET\/CT for nodal staging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24884","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:52:37Z","timestamp":1741701157000},"page":"777-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Pelvic Lymph Node Dissection on Early Oncological Outcomes in Intermediate\u2010Risk Prostate Cancer Patients With Node\u2010Negative PSMA PET"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-4607","authenticated-orcid":false,"given":"Baris","family":"Esen","sequence":"first","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Seymen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Armutlu","sequence":"additional","affiliation":[{"name":"Department of Pathology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Koseoglu","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Can","family":"Aykanat","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Zoro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Urology Tokat Gaziosmanpasa University Hospital Tokat Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Erdem","family":"Canda","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"},{"name":"RMK AIMES, Rahmi M. Koc Academy of Interventional Medicine, Education, and Simulation Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Kordan","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mevlana Derya","family":"Balbay","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Ertoy","family":"Baydar","sequence":"additional","affiliation":[{"name":"Department of Pathology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Onur","family":"Demirkol","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-1380","authenticated-orcid":false,"given":"Derya","family":"Tilki","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"},{"name":"Department of Urology University Hospital Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tar\u0131k","family":"Esen","sequence":"additional","affiliation":[{"name":"Department of Urology Koc University Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.05.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.10.072"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225667"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.10.044"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.08.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_430466"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.07.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30314-7"},{"key":"e_1_2_9_11_1","unstructured":"P.Cornford DT R. 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