{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:17:13Z","timestamp":1752549433197,"version":"3.40.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cabazitaxel (CBZ) is a key drug used for metastatic castration\u2010resistant prostate cancer (mCRPC). However, clinical trial data on CBZ in very elderly patients are still lacking. This study aimed to investigate the efficacy and feasibility of CBZ for mCRPC patients of \u2265\u200980 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 484 patients with mCRPC who started CBZ treatment between September 2019 and March 2024. Therapeutic efficacy (PSA response, progression\u2010free survival, overall survival, and safety profile) was compared between patients of &lt;\u200980 years of age (&lt;\u200980 group) and those of \u2265\u200980 years of age (\u2265\u200980 group). In addition, risk factors associated with grade \u2265\u20093 neutropenia in the \u2265\u200980 group were investigated using a logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three (15.1%) patients were included in the \u2265\u200980 group. Although more patients in the \u2265\u200980 group received a reduced dose relative to the &lt;\u200980 group, there was no significant difference in therapeutic efficacy between the two groups. The incidence of grade \u2265\u20093 neutropenia was similar between two groups (&lt;\u200980: 27.5% vs. \u2265\u200980: 31.5%). In the \u2265\u200980 group, BMI\u2009&lt;\u200922\u2009kg\/m<jats:sup>2<\/jats:sup> and neutrophil count \u2264\u20095000 cells\/\u00b5L were significantly associated with grade \u2265\u20093 neutropenia, with odds ratios of 5.28 (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) and 4.00 (<jats:italic>p<\/jats:italic>\u2009=\u20090.023), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In mCRPC patients of \u2265\u200980 years of age, CBZ showed similar safety and efficacy to younger patients. Our findings suggest that CBZ treatment with appropriate dose modification and prophylactic AE treatments may be still beneficial for elderly mCRPC patients in the current aging population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24889","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T16:43:46Z","timestamp":1742143426000},"page":"814-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Feasibility of Cabazitaxel for Very Elderly Patients of \u2265\u200980 Years of Age With Metastatic Castration\u2010Resistant Prostate Cancer: A Real\u2010World Multi\u2010Intuitional Analysis"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-9251","authenticated-orcid":false,"given":"Kotaro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Urology Kobe University Graduate School of Medicine Kobe 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