{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:15:39Z","timestamp":1791908139839,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain metastases (BMETS) from prostate cancer are rare. Hence, brain imaging in neurologically asymptomatic patients with advanced prostate cancer (aPC) is not routinely performed. Prostate\u2010specific membrane antigen (PSMA) PET\/CT uses a radiotracer that binds to prostate cancer epithelial cells and is FDA\u2010approved for initial staging for high\u2010risk prostate cancer, detecting prostate cancer recurrence, and determining eligibility for radionuclide therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report six patients with asymptomatic BMETS from aPC found on staging PSMA PET\/CT or MRI. Along with cranial MRI, PSMA PET\/CT may be useful for detecting asymptomatic intracranial metastasis in select patients with prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brain metastases were diagnosed in four patients by staging PSMA PET\/CT scan\u2014three after systemic disease progression and one during routine surveillance. In two other patients, BMETS were detected using MRI despite negative PSMA PET\/CT for brain lesions. All were neurologically asymptomatic. Three patients had undetectable serum prostate\u2010specific antigen (PSA) concentrations; one had neuroendocrine differentiation on histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with poorly differentiated or neuroendocrine aPC, BMETS may occur without neurologic symptoms and stable PSA. PSMA PET\/CT may complement brain MRI for identifying BMETS in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24890","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T12:18:36Z","timestamp":1741868316000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidental Brain Metastases From Prostate Cancer Diagnosed With PSMA PET\/CT and MRI: A Case Series and Literature Review"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-5360","authenticated-orcid":false,"given":"Mark Willy L.","family":"Mondia","sequence":"first","affiliation":[{"name":"Division of Neuro\u2010Oncology, Department of Neurology University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem P.","family":"Batchala","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, 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