{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:32:49Z","timestamp":1789853569189,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical trials rarely focus on elder patients with castration\u2010resistant prostate cancer (CRPC), and data on the outcomes of second\u2010generation androgen receptor signaling inhibitors (ARSIs) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ENABLE study for prostate cancer was an investigator\u2010initiated, multicenter, randomized controlled trial conducted in Japan to compare enzalutamide (ENZ) and abiraterone plus prednisolone (ABI). This sub\u2010analysis was performed to evaluate the efficacy and the safety profiles between patients aged \u2265\u200975 (older) and &lt;\u200975\u2009years (younger), and then between the ENZ and ABI arms in the older and the younger cohort separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ENZ arm included 41 younger and 51 older patients, while the ABI arm included 36 younger and 56 older patients. No significant differences in survival endpoints were observed between younger and older patients. Median time to prostate\u2010specific antigen (PSA) progression (TTPP) was 15.2\u2009months for younger and 21.2\u2009months for older patients (HR 0.84, 95% CI 0.53\u20131.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4647). Median overall survival (OS) was 33.7\u2009months for younger and 37.8\u2009months for older patients (HR 0.80, 95% CI 0.50\u20131.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3651). Among older patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009107), the ENZ arm had a TTPP of 21.2\u2009months compared to 10.1\u2009months for the ABI arm and an OS of 37.8\u2009months compared to 44.7\u2009months for the ABI arm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1506 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9321, respectively). Any grade and grade \u2265\u20093 adverse events were observed in 47 (61%) and 11 (14%) younger patients and 73 (68%) and 18 (17%) older patients, respectively. No significant differences were found in any grade or grade \u2265\u20093 adverse events between younger and older patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3487 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6885, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ARSIs demonstrated similar efficacy and safety in both younger and older patients. ENZ may be a more suitable option for older patients due to its higher PSA response rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>This trial was registered with the University Hospital Medical Information Network (UMIN) Center under identifier UMIN000015529.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.24897","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T04:50:44Z","timestamp":1743828644000},"page":"903-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Enzalutamide and Abiraterone Plus Prednisolone in Elder Castration\u2010Resistant Prostate Cancer Patients: A Sub\u2010Analysis From the ENABLE Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Takehiko","family":"Okamura","sequence":"first","affiliation":[{"name":"Department of Urology Anjo Kosei Hospital Anjo Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-9100","authenticated-orcid":false,"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Urology Anjo Kosei Hospital Anjo Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Urology Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Fukui\u2010ken Saiseikai Hospital Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Mita","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima City North Medical Center Asa Citizens Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Department of Urology University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Shobara Red Cross Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Urology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-7877","authenticated-orcid":false,"given":"Nobumichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Yoshio","sequence":"additional","affiliation":[{"name":"Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kanazawa Medical 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