{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:03:40Z","timestamp":1791241420620,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hormone therapy (HT) has greatly improved overall survival for prostate cancer patients, but may also influence cardiovascular health in an already high\u2010risk population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study examined participants in the <jats:italic>All of Us Research Program<\/jats:italic> with prostate cancer, had no prior history of adverse cardiovascular events, and were either treated or not treated with HT. HT was defined as GnRH agonists, GnRH antagonists, abiraterone, androgen antagonists, or androgen receptor pathway inhibitors. We defined adverse cardiovascular event as myocardial infarctions, heart failure, or strokes. Time to adverse cardiovascular event was defined using longitudinal electronic health record data. We evaluated whether HT use affected the risk of adverse cardiovascular events using a Cox regression model adjusted for established cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final cohort included 5156 participants. After adjustment for cardiovascular risk covariates, HT treatment was associated with increased risk of adverse cardiovascular event (HR: 1.22; 95% CI: 1.01\u20131.48; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). In participants with pre\u2010treatment dyslipidemia, HT usage was associated with increased risk of adverse cardiovascular events (HR: 1.52; 95% CI: 1.19\u20131.95; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In participants without pre\u2010treatment dyslipidemia, no association was found (HR: 0.96; 95% CI: 0.71\u20131.30; <jats:italic>p<\/jats:italic>\u2009=\u20090.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results show that HT\u2010associated cardiovascular risk may be synergistically amplified by dyslipidemia. These results suggest that risk stratification by dyslipidemia status may improve cardiovascular outcomes for prostate cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24913","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:24:24Z","timestamp":1749727464000},"page":"1077-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hormone Therapy Usage Is Associated With Adverse Cardiovascular Events in Prostate Cancer Patients of the <i>All of Us Research Program<\/i> Cohort"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-1505","authenticated-orcid":false,"given":"Yuanchu J.","family":"Yang","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee USA"},{"name":"Precision Health Informatics Section National Human Genome Research Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"Academic Internship Program National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-5661","authenticated-orcid":false,"given":"Chenjie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Precision Health Informatics Section National Human Genome Research Institute, National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry R.","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam C.","family":"Tran","sequence":"additional","affiliation":[{"name":"Precision Health Informatics Section National Human Genome Research Institute, National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Precision Health Informatics Section National Human Genome Research Institute, National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee USA"},{"name":"Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben H.","family":"Park","sequence":"additional","affiliation":[{"name":"Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Denny","sequence":"additional","affiliation":[{"name":"Precision Health Informatics Section National Human Genome Research Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"All of Us Research Program, Office of the Director National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_12_3_1","unstructured":"United States Cancer Statistics 2024.https:\/\/www.cdc.gov\/united-states-cancer-statistics\/publications\/prostate-cancer-stat-bite.html."},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"C.Dai H.Heemers andN.SharifiAndrogen Signaling in Prostate Cancer. 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