{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:30:10Z","timestamp":1793421010011,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While their indications overlap, no clinical trials have compared abiraterone and enzalutamide for overall survival (OS) in mCRPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A large, country\u2010wide health insurance database (2013\u20102023) was assessed for the OS comparison between abiraterone and enzalutamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 3497 patients were identified with first\u2010 (<jats:italic>n<\/jats:italic>\u2009=\u20092215) or second\u2010line (<jats:italic>n<\/jats:italic>\u2009=\u20091282) abiraterone or enzalutamide treatment (only 66 received both drugs sequentially). Enzalutamide\u2010treated patients had longer OS both in the first\u2010 (HR:0.84; 95%CI:0.74\u20100.96; <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and the second\u2010line setting (HR:0.88; 95%CI:0.78\u20100.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.043), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This health insurance\u2010registry\u2010based study suggests that, in the real\u2010world mCRPC setting, enzalutamide is superior to abiraterone in terms of OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24923","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T09:29:43Z","timestamp":1749374983000},"page":"1151-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010World Overall Survival Comparison of Enzalutamide and Abiraterone In First\u2010 and Second\u2010Line Setting of Metastatic Castration\u2010Resistant Prostate Cancer"],"prefix":"10.1002","volume":"85","author":[{"given":"Andr\u00e1s","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Blasszauer","sequence":"additional","affiliation":[{"name":"MedicalScan Ltd. Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Komka","sequence":"additional","affiliation":[{"name":"MedicalScan Ltd. Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Reibl","sequence":"additional","affiliation":[{"name":"MedicalScan Ltd. Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Hadaschik","sequence":"additional","affiliation":[{"name":"Department of Urology University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University Budapest Hungary"},{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-6584","authenticated-orcid":false,"given":"Pawel","family":"Rajwa","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  Austria"},{"name":"Second Department of Urology Centre of Postgraduate Medical Education Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ron","family":"So\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"Valikovics","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Nyir\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Szarvas","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"},{"name":"Department of Urology University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70379-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71205-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207506"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.032"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30688-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaa190"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00318-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00816-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.28444"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:05:22Z","timestamp":1753099522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,8]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pros.24923"],"URL":"https:\/\/doi.org\/10.1002\/pros.24923","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,8]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}