{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:47:07Z","timestamp":1784814427541,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate cancer (PCa) is the second most common solid tumor in men, and its incidence is strongly dependent on age. With the aging global population, this poses a significant medical and sociodemographic issue. As treatment options for castration\u2010resistant prostate cancer (CRPC) expand, the proportion of elderly patients with CRPC is expected to increase. Comprehensive genomic profiling (CGP) testing is becoming increasingly utilized for PCa; however, evidence on age\u2010related outcomes or benefits is limited. This study aimed to evaluate the efficacy of CGP testing in advanced elderly patients with CRPC compared to younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center, retrospective cohort study at Hiroshima University, including Japanese men aged \u2265\u200920 years who underwent CGP testing for CRPC between January 1, 2021, and May 31, 2024. Patients were categorized into the following two groups: the \u201cadvanced elderly group\u201d (\u2265\u200975 years) and the \u201cyounger group\u201d (&lt;\u200975 years). Clinical data were retrospectively extracted from medical records. CGP testing was performed using the FoundationOne\u00ae CDx, FoundationOne\u00ae Liquid CDx, Gurdant360\u00ae CDx, PleSSision Exome, or OncoGuide\u2122 NCC Oncopanel System. Pathogenic alterations were categorized into relevant subgroups. Statistical analyzes were performed to compare patient backgrounds, genomic subgroups, and outcomes between the age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 85 patients (median age: 74 years) were included in the analysis, with 38 and 47 in the advanced elderly and younger groups, respectively. No significant differences were observed in baseline clinical characteristics other than age. CGP testing identified 355 pathogenic variants (140 and 215 in the advanced elderly and younger groups, respectively), with similar distributions of alteration types across the two groups. Among the subgroups, DNA repair and homologous recombination repair\u2010related gene alterations were significantly more frequent in the younger group (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) than in the advanced elderly group. Overall survival (OS) did not differ significantly between the age groups. However, patients who received systemic chemotherapy based on CGP testing results had significantly better OS than those who did not receive systemic therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.045). This trend remained significant in the advanced elderly group (<jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CGP testing appears to offer clinical benefits for patients with CRPC, regardless of age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.24926","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:35:51Z","timestamp":1749602151000},"page":"1134-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive Genomic Profiling Testing for Castration\u2010Resistant Prostate Cancer in Advanced Elderly Patients: A Single\u2010Center Retrospective Cohort Study"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4434-2319","authenticated-orcid":false,"given":"Takafumi","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"},{"name":"Department of Urology Nakatsu Daiichi Hospital Nakatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"Tasaka","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohsuke","family":"Iwane","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Tasaka","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Kobatake","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Goriki","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Toshida","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Motonaga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tokumo","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutoshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Hiroshima University Hospital Hiroshima Japan"},{"name":"Department of Gastroenterology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayes","family":"Clair Nelson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Niitsu","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Urology Nakatsu Daiichi Hospital Nakatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiso","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hiroshima University Hospital Hiroshima Japan"},{"name":"Natural Science Center for Basic Research and Development Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Arihiro","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hinoi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Genetics, Genomic Medicine Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-6812","authenticated-orcid":false,"given":"Nobuyuki","family":"Hinata","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Biomedical &amp; Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.021"},{"key":"e_1_2_13_3_1","article-title":"An In\u2010Depth Look Into the Epidemiological and Etiological Aspects of Prostate Cancer: A Literature Review","volume":"15","author":"Al\u2010Ghazawi M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.05.005"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040720"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61389-X"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014618"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207506"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2020.05.018"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1619543"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246076"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00725-8"},{"key":"e_1_2_13_14_1","unstructured":"National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology: Prostate Cancer.version 4. 2024."},{"key":"e_1_2_13_15_1","unstructured":"EAU\u2010EANM\u2010ESTRO\u2010ESUR\u2010ISUP\u2010SIOG Guidelines on Prostate Cancer 2024 https:\/\/uroweb.org\/guidelines\/prostate-cancer."},{"key":"e_1_2_13_16_1","unstructured":"Advanced Prostate Cancer: AUA\/SUO Guideline https:\/\/www.auanet.org\/guidelines-and-quality\/guidelines\/advanced-prostate-cancer."},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00676-0"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2023.11.015"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15686"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-025-05505-8"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad148"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11125"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44276-024-00049-7"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911440"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz124"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.01.011"},{"key":"e_1_2_13_29_1","unstructured":"M. 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D.Nancie PetrucelliandT.PalBRCA1\u2212 and BRCA2\u2010Associated Hereditary Breast and Ovarian Cancer https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1247\/."},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.03.006"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.07.078"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.07.004"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01573-5"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2020.12.001"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_390396"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15203"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.24926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:05:12Z","timestamp":1753099512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.24926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pros.24926"],"URL":"https:\/\/doi.org\/10.1002\/pros.24926","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"2025-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}