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The serum and prostatic tissue levels of carbenicillin attained were sufficient to eradicate gram\u2010negative bacteria within the five time intervals studied. The ratio of prostatic tissue level of CB\u2010PC to the serum level of this agent increased in proportion to the grading of round cell infiltration of the prostatic tissue. The results of this study point to the clinical usefulness of CB\u2010PC in the treatment of chronic and acute prostatitis.<\/jats:p>","DOI":"10.1002\/pros.2990010310","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:38:44Z","timestamp":1172014724000},"page":"351-356","source":"Crossref","is-referenced-by-count":0,"title":["Levels of carbenicillin in serum and prostatic tissue after intravenous administration in patients with benign prostatic hyperplasia"],"prefix":"10.1002","volume":"1","author":[{"given":"Teruo","family":"Mishina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Miyakoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Kaiho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1117","article-title":"Laboratory and clinical studies on carbenicillin","volume":"17","author":"Mashimo K","year":"1969","journal-title":"Chemotherapy"},{"key":"e_1_2_1_3_2","first-page":"1095","article-title":"Fundamental studies on carbenicillin","volume":"17","author":"Nishida M","year":"1969","journal-title":"Chemotherapy"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61919-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/219139a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61782-8"},{"key":"e_1_2_1_7_2","first-page":"2210","article-title":"Laboratory evaluation of Carfecillin, a carbenicillin phenyl ester. 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