{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:11:29Z","timestamp":1699834289627},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9331,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostatic secretion protein (PSP) is a major component of rat prostatic cytosol, and this protein is also found in the prostatic fluid. Purified PSP was found to inhibit the nuclear uptake of the [<jats:sup>3<\/jats:sup>H]methyltrienolone\u2010receptor complex in vitro. Furthermore, purified PSP inhibited the binding of this androgen\u2010receptor complex to DNA\u2010cellulose. It is suggested that these effects of PSP may represent an intracellular control system regulating the concentration of PSP. Administration of estramustine, the dephosphorylated metabolite of the anti\u2010cancer drug estramustine phosphate (Estracyt\u00ae), to rats was found to decrease the weight of the prostate gland but to maintain the concentration of PSP, calculated as mg PSP\/mg protein, at a constant level. In contrast, castration or administration of estradiol\u201017\u03b2 valerate decreased the weight of the prostate gland as well as the concentration of PSP. These findings indicate that the mechanism of action of estramustine is at least partially different from that of estradiol\u201017\u03b2. Furthermore, it is suggested that estramustine may exert part of its action through its effects on the concentration of PSP.<\/jats:p>","DOI":"10.1002\/pros.2990020104","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:38:34Z","timestamp":1172014714000},"page":"23-33","source":"Crossref","is-referenced-by-count":11,"title":["Influence of prostatic secretion protein on uptake of androgen\u2010receptor complex in prostatic cell nuclei"],"prefix":"10.1002","volume":"2","author":[{"given":"\u00c5Ke","family":"Pousette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Bj\u00f6rk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Carlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Forsgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"H\u00f6gberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010\u00c5ke","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"56","volume-title":"Steroid Cell Interaction","author":"King R","year":"1974"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.7.3149"},{"key":"e_1_2_1_4_2","first-page":"181","volume-title":"Prostate Cancer and Hormone Receptors","author":"H\u00f6gberg B","year":"1979"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.34b-0155"},{"key":"e_1_2_1_6_2","unstructured":"Pousette\u00c5 Bj\u00f6rkP Carlstr\u00f6mK ForsgrenB GustafssonJ\u2010\u00c5 H\u00f6gbergB: Influence of sex hormones on prostatic secretion protein a major protein in rat prostate.Cancer Res.(in press)."},{"key":"e_1_2_1_7_2","first-page":"5155","article-title":"Binding characteristics of a major protein in rat ventral prostate cytosol that interacts with estramustine, a nitrogen mustard derivative of 17\u03b2\u2010estradiol","volume":"39","author":"Forsgren B","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365597109133586"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02280.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90180-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1700115"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00737a007"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1949.tb27297.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1420273"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(79)90397-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-6-1408"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-4-1090"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1016\/S0021-9258(18)50537-8","article-title":"Prostatein. A major secretory protein of the rat ventral prostate","volume":"254","author":"Lea OA","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_20_2","first-page":"16","article-title":"Androgen receptors. Steroid and tissue\u2010specific retention of a 17\u03b2\u2010hydroxy\u20105\u03b1\u2010androstan\u20103\u2010one protein complex by the cell nuclei of ventral prostate","volume":"246","author":"Fang S","year":"1971","journal-title":"J Biol Chem"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.12.5969"},{"key":"e_1_2_1_22_2","first-page":"128","article-title":"The absorption metabolism and excretion of Estracyt (NSC 89199) in patients with prostatic cancer","volume":"14","author":"Plym\u2010Forsell G","year":"1976","journal-title":"Invest Urol"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990020104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990020104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:38:56Z","timestamp":1699767536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990020104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/pros.2990020104"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990020104","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}